复方芪麻胶囊的提取工艺研究
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篇名: 复方芪麻胶囊的提取工艺研究
TITLE:
摘要: 目的:优化复方芪麻胶囊的提取工艺。方法:采用药效实验法,以大鼠血压降低值为指标,筛选样品制备工艺(A工艺为药材全煎;B工艺为天麻细粉与其余煎煮后药材混合);采用单因素和正交试验法,以黄芪甲苷含量、毛蕊异黄酮葡萄糖苷含量和固形物质量为指标,以加水倍数、煎煮时间、煎煮次数为因素优化提取工艺并进行验证试验。结果:药效实验表明B工艺样品降压作用更优;该工艺中其余药材的最优提取工艺为药材每次加12倍量水煎煮1.5 h,共煎煮3次;验证试验显示黄芪甲苷、毛蕊异黄酮葡萄糖苷的平均提取率分别为64.02%、51.97%,平均固形物质量为5.69 g(RSD≤1.92%,n=3)。结论:优化的提取工艺稳定、可行。
ABSTRACT: OBJECTIVE: To optimize the extraction technology of Compound qima capsules. METHODS: With the blood pressure lowering of rats as index, pharmacological efficacy test was used to screen the preparation technology (A was whole herb decoction; B was Gastrodia elata fine powder mixed with other decocted medical materials). The extraction technology was optimized by single factor and orthogonal test using the contents of astragaloside and isoflavone grape glycosides and the quality of solid as indexes, with added water, decoction time, decoction times as factors; and the verification test was carried out. RESULTS: Pharmacological efficacy test showed that antihypertensive effect of sample by technology B was superior. The optimal extraction condition of other medical materials of technology B was as follows as 12-fold water per time, decocting for 1.5 h, for 3 times. In verification test, average extraction rates of astragaloside and isoflavone grape glycosides were 64.02% and 51.97%, and average value of the quality of solid was 5.69 g(RSD≤1.92%, n=3). CONCLUSIONS: The optimized extraction technology is stable and feasible.
期刊: 2016年第27卷第22期
作者: 王洛临,吴小斌,周蓉,张建军,袁柳萍
AUTHORS: WANG Luolin,WU Xiaobin,ZHOU Rong,ZHANG Jianjun,YUAN Liuping
关键字: 复方芪麻胶囊;降压作用;提取工艺;黄芪甲苷;毛蕊异黄酮葡萄糖苷;正交试验
KEYWORDS: Compound qima capsules; Antihypertensive effect; Extraction technology; Astragaloside; Isoflavone grape glycosides; Orthogonal test
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