左氧氟沙星和曲安奈德双载药眼用凝胶的制备
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篇名: 左氧氟沙星和曲安奈德双载药眼用凝胶的制备
TITLE:
摘要: 目的:制备左氧氟沙星和曲安奈德双载药眼用凝胶。方法:以盐酸左氧氟沙星和醋酸曲安奈德为主药、卡波姆940P为凝胶基质、羟丙甲纤维素(HPMC K4M)为增黏剂,制备左氧氟沙星和曲安奈德双载药眼用凝胶。以凝胶的溶散时间为指标,采用单因素试验筛选处方中卡波姆940P和HPMC K4M的浓度;测定所制双载药眼用凝胶的溶散时间、黏度和2种主药的含量。结果:双载药眼用凝胶处方中卡波姆940P的浓度为0.4%、HPMC K4M的浓度为1.2%。所制双载药眼用凝胶的溶散时间不低于24 h,黏度为1 142.67 Pa·s;盐酸左氧氟沙星含量占标示量的97.3%(RSD=0.84%,n=3),醋酸曲安奈德含量占标示量的92.97%(RSD=1.32%,n=3)。结论:成功制得左氧氟沙星和曲安奈德双载药眼用凝胶。
ABSTRACT: OBJECTIVE: To prepare Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel. METHODS: Using levofloxacin hydrochloride and triamcinolone acetonide as main components, carbopol-940P as base material, HPMC K4M as tackifier, Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel was prepared. Using dissolution time as index, the contents of carbopol-940P and HPMC K4M were determined by single factor test, and dissolution time, viscosity and the contents of 2 main components were also determined. RESULTS: The concentrations of carbopol-940P and HPMC K4M were 0.4% and 1.2%, separately. The dissolution time was more than 24 h and viscosity was 1 142.67 Pa·s. The content of levofloxacin hydrochloride was 97.3% of labelled amount (RSD=0.84%, n=3), and that of triamcinolone acetonide was 92.97% of labelled amount (RSD=1.32%, n=3). CONCLUSIONS: Levofloxacin and triamcinolone acetonide double-loaded ophthalmic gel has been prepared successfully.
期刊: 2016年第27卷第22期
作者: 樊莲莲,杨青青,徐翰林,张培雯,苏文成,黄亚,陈宏
AUTHORS: FAN Lianlian,YANG Qingqing,XU Hanlin,ZHANG Peiwen,SU Wencheng,HUANG Ya,CHEN Hong
关键字: 左氧氟沙星;曲安奈德;眼用凝胶
KEYWORDS: Levofloxacin; Triamcinolone acetonide; Ophthalmic gel
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