OPRM1 A118G多态性对我国汉族癌痛患者阿片类药物使用剂量的影响
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篇名: OPRM1 A118G多态性对我国汉族癌痛患者阿片类药物使用剂量的影响
TITLE:
摘要: 目的:探讨μ阿片受体基因(OPRM1)A118G多态性对我国汉族癌痛患者阿片类药物使用剂量的影响,为其个体化用药提供参考。方法:选择某“三甲”医院中、重度汉族癌痛患者66例,采用荧光原位杂交技术检测其OPRM1 A118G多态性,比较不同基因型癌痛患者阿片类药物的使用剂量。结果:66例患者中,AA、AG、GG基因型患者分布频率分别为36.36%、53.03%、10.61%,A、G等位基因的分布频率分别为62.88%、37.12%;AA、AG、GG基因型患者阿片类药物的日剂量分别为(21.67±13.41)、(42.00±32.18)、(87.14±73.65)mg,差异有统计学意义(P<0.001)。39例首次使用阿片类药物的患者中,6例AA基因型、15例AG基因型患者进行了剂量调整,差异有统计学意义(P=0.026);剂量调整后,AA、AG基因型患者的日剂量分别为(16.11±9.16)、(28.57±18.52)mg,差异有统计学意义(P=0.011)。结论:OPRM1 A118G基因型可影响我国汉族癌痛患者阿片类药物的使用剂量,其基因多态性可作为指导阿片类药物使用剂量的依据。
ABSTRACT: OBJECTIVE: To provide reference for the individualized treatment of opioid drugs by investigating the effects of OPRM1 A118G gene polymorphism on opioids dosage in Chinese Han Population patients with cancer pain. METHODS: 66 Chinese Han Population patients with medium and severe cancer pain were selected from a third grade class A hospital. Using fluorescence in-situ hybridization, OPRM1 A118G genotypes were detected to compare the opioids dosage of different genotype in patients with cancer pain. RESULTS: Among 66 patients, distribution frequency of AA, AG and GG genotype were 36.36%, 53.03% and 10.61%, respectively; those of A and G allele were 62.88% and 37.12%; the daily dosage of opioids in AA, AG, GG genotype patients respectively were (21.67±13.41), (42.00±32.18) and (87.14±73.65)mg, with statistical significance (P<0.001). Among 39 patients receiving opioids for the first time, the dosage of 6 AA genotype patients and 15 AG genotype patients had been adjusted, with statistical significance (P=0.026). After adjusting dosage, daily dosage of AA genotype and AG genotype patients were (16.11±9.16) and(28.57±18.52)mg, with statistical significance (P=0.011). CONCLUSIONS: OPRM1 A118G genotype can influence the dosage of opioid in Chinese Han Population patients with cancer pain, and gene polymorphism can be used as evidence for dosage guide of opioids.
期刊: 2016年第27卷第20期
作者: 李颖,吴飞雪,孙立,李翔,汪永忠
AUTHORS: LI Ying,WU Feixue,SUN Li,LI Xiang,WANG Yongzhong
关键字: μ阿片受体基因;基因多态性;癌痛;阿片类药物;剂量;汉族
KEYWORDS: OPRM1; Gene polymorphism; Cancer pain; Opioids; Dosage; Han population
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