阿奇霉素序贯疗法用于儿童支原体肺炎的临床观察
x

请在关注微信后,向客服人员索取文件

篇名: 阿奇霉素序贯疗法用于儿童支原体肺炎的临床观察
TITLE:
摘要: 目的:观察阿奇霉素序贯疗法用于儿童支原体肺炎的疗效和安全性。方法:67例支原体肺炎患儿随机分为对照组(34例)和观察组(33例)。两组患儿均给予退热、止咳等常规治疗,并辅以营养支持。在此基础上,对照组患儿给予注射用乳糖酸阿奇霉素10 mg/kg,加入5%葡萄糖注射液200 ml中,静脉滴注,每日1次;观察组患儿给予注射用乳糖酸阿奇霉素(用法用量同对照组)静脉滴注5 d后,改用阿奇霉素干混悬剂10 mg/(kg·d),口服,连用3 d后停4 d。两组疗程均为7~10 d。观察两组患儿的临床疗效,退热时间、咳嗽消失时间、肺部啰音消失时间,治疗前后肺功能指标及不良反应发生情况。结果:两组患儿总有效率、退热时间、咳嗽消失时间、肺部啰音消失时间比较,差异均无统计学意义(P>0.05)。治疗后,两组患儿肺功能指标水平均显著高于同组治疗前,差异均有统计学意义(P<0.01),但组间比较差异无统计学意义(P>0.05)。观察组患儿不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论: 在常规治疗的基础上, 阿奇霉素序贯治疗儿童支原体肺炎的疗效与未采用序贯疗法相当,但安全性优于未采用序贯疗法。
ABSTRACT: OBJECTIVE: To observe the efficacy and safety of azithromycin sequential therapy in the treatment of mycoplasma pneumonia in children. METHODS: 67 children with mycoplasma pneumonia were randomly divided into control group (34 cases) and observation group (33 cases). All children received conventional treatment, such as fever, cough, supplemented by nutrition support; based on it, control group received 10 mg/kg Azithromycin for injection, adding into 5% Glucose injection by intravenous drip in 200 ml, once a day; observation group received azithromycin (the same dosage with control group) after intravenous drip 5 d, switched to 10 mg/(kg·d) Azithromycin dry suspension, orally, then stopped 4 d after continuous 3 d. The treatment course was 7-10 d. Clinical efficacy, disappearance time of fever, cough and lung rales, and lung indexes before and after treatment, and the incidence of adverse reactions in 2 groups were observed. RESULTS: There were no significant differences in the total effective rate, disappearance time of fever, cough and lung rales in 2 groups (P>0.05). After treatment, the lung function indexes were significantly higher than before, the differences were statistically significant (P<0.01), but there was no significant difference between 2 groups (P>0.05). The incidence of adverse reactions in observation group was significantly lower than control group, the difference was statistically significant (P<0.05). CONCLUSIONS: Based on conventional treatment, azithromycin sequential therapy shows similar efficacy to without sequential therapy in the treatment of mycoplasma pneumonia in children, but with better safety.
期刊: 2016年第27卷第18期
作者: 楚加元,许洲
AUTHORS: CHU Jiayuan,XU Zhou
关键字: 儿童;支原体肺炎;阿奇霉素;序贯疗法;疗效;安全性
KEYWORDS: Children; Mycoplasma pneumonia; Azithromycin; Sequential therapy; Efficacy; Safety
阅读数: 385 次
本月下载数: 2 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!