南京地区34家医院2011-2014年抗抑郁药使用分析
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篇名: 南京地区34家医院2011-2014年抗抑郁药使用分析
TITLE:
摘要: 目的:为抗抑郁药临床合理使用提供参考。方法:采用世界卫生组织推荐的限定日剂量(DDD)分析法,对南京地区34家医院2011-2014年抗抑郁药的主要品种、销售金额、用药频度(DDDs)和日均费用(DDC)等进行统计分析。结果:南京地区34家医院2011-2014年抗抑郁药的销售金额和DDDs呈逐年上升趋势,年平均增长率分别为18.21%和19.25%。帕罗西丁、舍曲林各年度DDDs分别列第1、2位;托莫西汀、曲唑酮和度洛西汀各年度DDC均列前3位;帕罗西汀、舍曲林、文法拉辛和艾司西酞普兰各年度销售金额均列前4位;帕罗西汀、米氮平、西肽普兰等的销售金额与DDDs的同步性较好,序号比接近或等于1.00。结论:南京地区34家医院抗抑郁药的临床使用结构和层次较为合理,选择性5-羟色胺(5-HT)再摄取抑制剂和选择性5-HT和去甲肾上腺素再摄取抑制剂两类药物的应用占主导地位;新型抗抑郁药的使用也日益广泛,发展前景广阔。
ABSTRACT: OBJECTIVE: To provide reference for rational use of antidepressant drugs in the clinic. METHODS: By DDD analysis recommended by WHO, the utilization of antidepressant drugs in 34 hospital from Nanjing area during 2011-2014 were analyzed statistically in respects of main type, consumption sum, DDDs and DDC, etc. RESULTS: The consumption sum and DDDs of antidepressants were increased year by year in 34 hospital from Nanjing area during 2011-2014, with the average annual growth rate of 18.21% and 19.25% respectively. The top 2 drugs by DDDs were paroxetine and setraline; DDC of tomoxetine, trazodone and dutoxetine took up the first 3 place; consumption sum of paroxetine, setraline, venlafaxine and escitalopram took up the first 4 places; consumption sum of paroxetine, mirtazapine and citalopram synchronized with their DDDs, and serial number ratio was close to or equal to 1.00. CONCLUSIONS: The use of antidepressant drugs in 34 hospitals from Nanjing area is rational in structure and level; selective 5-hydroxytryptamine (5-HT) reuptake inhibitors (SSRI) and selective 5-HT noradrenaline reuptake inhibitor (SNRI) take up the predominant place; new type of antidepressant drugs are used widely and of great use potentiality in the future.
期刊: 2016年第27卷第17期
作者: 吴斌,刘慧
AUTHORS: WU Bin,LIU Hui
关键字: 抗抑郁药;销售金额;用药频度;日均费用;用药分析
KEYWORDS: Antidepressants; Consumption sum; DDD; DDC; Analysis of drug use
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