香丹注射液与丹参川芎嗪注射液治疗冠心病不稳定型心绞痛的最小成本分析
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篇名: 香丹注射液与丹参川芎嗪注射液治疗冠心病不稳定型心绞痛的最小成本分析
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摘要: 目的:比较香丹注射液与丹参川芎嗪注射液治疗冠心病不稳定型心绞痛的成本差异,为临床合理、经济选药提供参考。方法:42例冠心病不稳定型心绞痛患者按照不同的药物治疗方案分为香丹注射液组(A组,20例)和丹参川芎嗪注射液组(B组,22例)。两组患者均根据具体临床情况给予常规对症治疗;在此基础上,A组患者给予香丹注射液20 ml静脉滴注,qd;B组患者给予丹参川芎嗪注射液10 ml静脉滴注,qd,疗程均为14 d。比较两组患者的临床疗效和不良反应发生情况,并进行最小成本分析。结果:治疗后,A、B组患者的总有效率分别为95.00%、95.45%,差异无统计学意义(P>0.05);不良反应发生率比较,差异亦无统计学意义(P>0.05)。两组患者除药品费用外的所有费用均相等;用最小成本分析法,A组所用药品成本为77.28元,总成本为705.88元;B组所用药品成本为 1 310.40元,总成本为1 939.00元,A组药品成本和总成本明显低于B组,差异有统计学意义(P<0.05)。敏感度分析结果与最小成本分析结果一致。结论:采用香丹注射液治疗冠心病不稳定型心绞痛的成本比丹参川芎嗪注射液更低,用药更经济。
ABSTRACT: OBJECTIVE: To compare the cost of Xiangdan injection and Danshen chuanxiongqin injection in the treatment of unstable angina pectoris of coronary heart disease, and to provide reference for rational and economic drug selection. METHODS: 42 inpatients with unstable angina pectoris of coronary heart disease were divided into Xiangdan injection group (group A, 20 cases) and Danshen chuanxiongqin injection group (group B, 22 cases). Two groups were given conventional symptomatic treatment according to the specific clinical situation; on this basis, group A was given Xiangdan injection 20 ml intravenously, qd; group B was given Danshen chuanxiongqin injection 10 ml intravenously, qd, for 14 d. Clinical efficacy and the occurrence of ADR were compared between 2 groups, and cost-minimization analysis was conducted. RESULTS: After treatment, total effective rate of group A and B was 95.00% and 95.45%, without statistical significance (P>0.05); there was also no statistical significance in the incidence of ADR (P>0.05). The costs of 2 groups were equal in addition to the cost of drugs. According to cost-minimization analysis, the drug cost of group A was 77.28 yuan and total cost was 705.88 yuan; the drug cost of group B was 1 310.40 yuan and total cost was 1 939.00 yuan; the drug cost and total cost of group A were far more less than that of group B, with statistical significance (P<0.05). The results of sensitivity analysis were consistent with it. CONCLUSIONS: The cost of Xiangdan injection is lower and more economical than that of Danshen chuanxiongqin injection in the treatment of unstable angina pectoris of coronary heart disease.
期刊: 2016年第27卷第17期
作者: 朱玉芬,王玉
AUTHORS: ZHU Yufen,WANG Yu
关键字: 香丹注射液;丹参川芎嗪注射液;冠心病不稳定型心绞痛;最小成本分析
KEYWORDS: Xiangdan injection; Danshen chuanxiongqin injection; Unstable angina pectoris of coronary heart disease; Cost-minimization analysis
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