精乌胶囊联合贝那普利对2型糖尿病肾病患者尿白蛋白及血肌酐水平的影响
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篇名: 精乌胶囊联合贝那普利对2型糖尿病肾病患者尿白蛋白及血肌酐水平的影响
TITLE:
摘要: 目的:观察精乌胶囊联合贝那普利对2型糖尿病肾病尿白蛋白排泄率(UAER)及血肌酐(Cr)水平的影响。方法:将60例2型糖尿病肾病患者按随机数字表法分为对照组和观察组,各30例。对照组患者4例失访,1例因出现刺激性干咳退出研究;观察组患者4例失访。对照组患者口服贝那普利氢氯噻嗪片5 mg,qd;观察组在对照组基础上加服精乌胶囊2.7 g,tid。两组患者均治疗12周。观察两组患者治疗前后UAER、Cr水平及不良反应情况。结果:治疗前,两组患者UAER水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者UAER水平显著降低且低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后Cr水平比较,差异无统计学意义(P>0.05)。治疗后,对照组患者出现刺激性干咳1例,观察组患者未见明显不良反应发生。结论:精乌胶囊联合贝那普利能明显降低2型糖尿病肾病患者UAER,不加重患者肾脏负担,安全性较好。
ABSTRACT: OBJECTIVE: To observe the effect of urinary albumin excretion rate(UAER) and serum creatinine (Cr) level of Jingwu capsule combined with benazepril in the treatment of urinary microalbumin of type 2 diabetic nephropathy. METHODS: 60 patients with urinary microalbumin of type 2 diabetic nephropathy were randomly divided into control group and observation group, with 30 cases in each group. There were 4 cases of follow-up failure and 1 case of irritant dry cough in control group; there were 4 cases of follow-up failure in observation group. Control group was given benazepril 5 mg, qd; observation group was additionally given Jingwu capsule 2.7 g,tid, on the basis of control group. Both group were treated for 12 weeks. UAER and Cr level, ADR were observed in 2 groups before and after treatment. RESULTS: Before treatment, there was no statistical significance in UAER level between 2 groups (P>0.05); after treatment, UAER level of observation group was significantly lower than that of control group, with statistical significance (P<0.05). There was no statistical significance in Cr level between 2 groups before and after treatment (P>0.05). After treatment, one patient of control group suffered from irritant dry cough, and no obvious ADR was found in observation group. CONCLUSIONS: Jingwu capsule combined with benazepril can decrease urinary albumin in patient with type 2 diabetic nephropathy and doesn’t incease the burden on pationts with renal with good safety.
期刊: 2016年第27卷第14期
作者: 王小翠,付晓凤,张瑞,童强
AUTHORS: WANG Xiaocui,FU Xiaofeng,ZHANG Rui,TONG Qiang
关键字: 精乌胶囊;2型糖尿病肾病;尿白蛋白;血肌酐
KEYWORDS: Jingwu capsule; Type 2 diabetic nephropathy; Urinary albumin; Cr
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