阿卡波糖联合格列吡嗪对初诊2型糖尿病患者血糖、血脂、胰岛功能与血清微小核糖核酸的影响
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篇名: 阿卡波糖联合格列吡嗪对初诊2型糖尿病患者血糖、血脂、胰岛功能与血清微小核糖核酸的影响
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摘要: 目的:探讨阿卡波糖联合格列吡嗪对初诊2型糖尿病患者血糖、血脂、胰岛功能与血清微小核糖核酸(miRNA)的影响。方法:80例初诊2型糖尿病患者采用随机数字表法分为研究组和对照组,各40例。对照组患者给予格列吡嗪缓释片口服,起始剂量为每日5 mg,最大剂量为每次5~10 mg,bid;研究组患者在对照组治疗基础上加用阿卡波糖片,起始剂量为每次50 mg,tid,最大剂量为每次50~100 mg,tid,进餐时同服。两组疗程均为12周。比较两组患者治疗前后血糖、血脂、胰岛功能指标与血清miRNA检测水平的差异,并观察不良反应发生情况。结果:治疗后,两组患者空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数均较治疗前显著降低,胰岛B细胞功能、空腹C肽、餐后2 h C肽、空腹胰岛素、餐后2 h胰岛素均较治疗前显著升高,且研究组变化更为显著,差异均具有统计学意义(P<0.05)。治疗后两组患者的miR-29a光密度(OD)值均较治疗前显著降低、miR-375 OD值均较治疗前显著升高,且研究组变化更为显著,差异均具有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:阿卡波糖联合格列吡嗪对初诊2型糖尿病患者的降糖、改善胰岛、改善血清miRNA水平的作用均显著优于单用格列吡嗪。
ABSTRACT: OBJECTIVE: To explore the effects of acarbose combined with glipizide on blood glucose, blood lipid, islet function and serum miRNA of newly diagnosed type 2 diabetes patients. METHODS: 80 patients with newly diagnosed type 2 diabetic patients were randomly divided into research group and control group with 40 cases in each group. Control group was given Glipizide sustained-release tablet orally with initial dose of 5 mg/d and maximal dose of 5-10 mg/time, bid; research group was additionally given Acarbose tablet with initial dose of 50 mg/time, tid, and maximal dose of 50-100 mg/time, bid, with a meal, on the basis of control group. Treatment course of 2 groups lasted for 12 weeks. The blood glucose, blood lipid, islet function index, serum miRNA and ADR were compared between 2 groups before and after treatment. The occurrence of ADR was observed. RESULTS: After treatment, FPG, 2 h PG, glycosylated hemoglobin and HOMA-IR of 2 groups decreased significantly, and islet B cell function, C-P, 2 h C-P, FINS and 2 h INS value increased significantly, and more significant in study group, with statistical significance (P<0.05). After treatment, miR-29a OD value of 2 groups decreased significantly, and miR-375 OD value increased significantly, and more significant in study group, with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS: Acarbose combined with glipizide is better than glipizide alone in decreasing blood glucose, improving islet function and serum miRNA levels in newly diagnosed type 2 diabetes patients.
期刊: 2016年第27卷第11期
作者: 刘丽楠,李敬华,王素莉,程晨
AUTHORS: LIU Linan,LI Jinghua,WANG Suli,CHENG Chen
关键字: 阿卡波糖;格列吡嗪;联合用药;初诊患者;2型糖尿病;胰岛功能;微小核糖核酸
KEYWORDS: Acarbose; Glipizide; Drug combination; Newly diagnosed patients; Type 2 diabetes; Islet function; miRNA
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