药物利用评估方法在肿瘤科糖皮质激素类药物使用评价中的作用
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篇名: 药物利用评估方法在肿瘤科糖皮质激素类药物使用评价中的作用
TITLE:
摘要: 目的:探讨建立适用于我院肿瘤科使用糖皮质激素类药物(GCs)的药物利用评估(DUE)标准,对该类药品的使用进行合理性评价。方法:初步建立适用于我院肿瘤科使用GCs的DUE标准,主要从用药适应证、用药过程监测、用药结果3个方面进行评估。通过医院信息系统分别收集和整理我院肿瘤科2013年4-12月(干预前)300例和2014年6月-2015年3月(干预后)300例使用GCs患者的病历资料,评估其GCs使用情况。结果:我院使用频率最高的GCs为地塞米松磷酸钠注射液(占抽查病例数的82.34%),其次分别是醋酸地塞米松片(占15.33%)和醋酸泼尼松片(占2.33%)。我院肿瘤科GCs的使用以防治放/化疗呕吐为目的最为常见(占用药目的合计例次的55.55%),其次为抗炎治疗(占14.19%)和化疗药物预处理(占12.76%)。干预后,GCs在肿瘤疾病中合理用药水平有较大提高,用药剂量与疗程的不合格率从6.87%降至3.95%,无指征用药率从3.58%降至2.74%。结论:通过建立DUE标准,在督导临床合理用药的过程中不断完善标准,可促进肿瘤科GCs的合理使用。
ABSTRACT: OBJECTIVE: To explore the establishment of DUE criteria for the evaluation of glucocorticoids (GCs) use in oncology department of our hospital, and to evaluate the rationality of glucocorticoid use. METHODS: DUE criteria for GCs in our hospital was established preliminary, and used to evaluate medication indication, medication course, medication results, etc. Medical records of 300 patients receiving GCs were collected from oncology department of our hospital during Apr. to Dec. in 2013 (before intervention) and Jun. 2014 to Mar. 2015 (after intervention) via hospital information system. The application of GCs was evaluated. RESULTS: Pexamethasone sodium phosphate injection was used most frequently in our hospital (82.34%), followed by Dexamethasone acetate tablet (15.33%) and prednisone asetate tablets(2.33%). The mest common purpose of GCs use in oncology department of our hospital is radiotherapy and chemotherapy induced vomiting prevention and treatment (55.55% of total case), followed by anti-inflammatory therapy (14.19%) and chemotheraphy drug pretreatment (12.76%). After intervention, rational use of GCs for tumor had been improved greatly, and the rate of unqualified drug dosage and medication course decreased from 6.87% to 3.95%, and that of decreased from 3.58% to 2.74%. CONCLUSIONS: The establishment of DUE criteria and continuous criteria improvement during clinical rational drug use guidance can promote rational use of GCs in oncology department.
期刊: 2016年第27卷第8期
作者: 胡钰,罗洁丽,黄艳芳,白敦耀,李璐,吴柳婷
AUTHORS: HU Yu,LUO Jieli,HUANG Yanfang,BAI Dunyao,LI Lu,WU Liuting
关键字: 药物利用评估;糖皮质激素;肿瘤科;合理用药
KEYWORDS: DUE; Glucocorticoids; Oncology department; Rational drug use
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