参芪扶正注射液联合尼莫地平对脑梗死恢复期患者血液指标的影响
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篇名: 参芪扶正注射液联合尼莫地平对脑梗死恢复期患者血液指标的影响
TITLE:
摘要: 目的:观察参芪扶正注射液联合尼莫地平片对脑梗死恢复期患者血液指标的影响。方法:选取脑梗死恢复期患者58例,按随机数字表法分为对照组和观察组,各29例,对照组患者给予尼莫地平片30 mg,tid;观察组患者在对照组基础上加用参芪扶正注射液250 ml,qd,ivgtt,两组患者均治疗14 d。治疗后,观察两组患者血清超敏C反应蛋白(hs-CRP)、趋化因子Fractalkine、组织型纤溶酶原激活物(tPA)、组织型纤溶酶原激活物抑制剂(PAI)-1、血液流变学指标及血浆纤维蛋白原(FIB)水平。结果:治疗后,观察组患者血清hs-CRP、趋化因子Fractalkine、血液流变学指标及血浆PAI-1、FIB活性水平显著降低,血浆tPA活性水平显著升高,与对照组比较,差异均有统计学意义(P<0.05)。结论:参芪扶正注射液联合尼莫地平片能够显著改善脑梗死恢复期患者血清hs-CRP、趋化因子Fractalkine、血液流变学指标及血浆PAI-1、FIB、tPA水平,提高血浆活性。
ABSTRACT: OBJECTIVE: To observe the effects of Shenqi fuzheng injection combined with Nimodipine tablet on blood indicators of cerebral infarction patients in the recovery period. METHODS: 58 patients diagnosed as cerebral infarction in the recovery period were collected and randomly divided into control group and trial group, with 29 cases in each group. Control group  was given Nimodipine tablet 30 mg, tid; trial group was additionally given Shenqi fuzheng injection 250 ml, qd, ivgtt. Both group received 14 d of treatment. After treatment, the levels of serum hs-CRP, Fractalkine, tPA, PAI-1, blood rheology index and plasma fibrinogen (FIB) were observed in 2 groups. RESULTS: After treatment, the levels of serum hs-CRP, Fractalkine, blood rheology index PAI-1 and FIB decreased in trial group, while tPA activity increased; there was statistical significance between trial group and control group (P<0.05). CONCLUSIONS: Shenqi fuzheng injection combined with Nimodipine tablet can significantly improve the serum hs-CRP and Fractalkine levels, blood rheology indicators, PAI-1 and FIB, and improve tPA activity.
期刊: 2016年第27卷第5期
作者: 陈思,陆斌,尹文伟,毕堃
AUTHORS: CHEN Si,LU Bin,YIN Wenwei,BI Kun
关键字: 参芪扶正注射液;尼莫地平片;脑梗死恢复期
KEYWORDS: Shenqi fuzheng injection; Nimodipine tablet; Cerebral infarction recovery period
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