甘精胰岛素对比预混胰岛素治疗2 型糖尿病疗效与安全性的
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篇名: 甘精胰岛素对比预混胰岛素治疗2 型糖尿病疗效与安全性的
TITLE:
摘要:

目的:系统评价甘精胰岛素对比预混胰岛素治疗2 型糖尿病的疗效与安全性,以为临床提供循证参考。方法:计算机检

索PubMed、中国期刊全文数据库、万方数据库和中文科技期刊数据库,收集甘精胰岛素(试验组)对比预混胰岛素(对照组)治疗2

型糖尿病疗效与安全性的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用改良后的Jadad 量表进行质量

评价,采用Rev Man 5.0 统计软件进行Meta 分析。结果:共纳入10 项RCT,合计1 655 例患者。Meta 分析结果显示,甘精胰岛素在

降低糖化血红蛋白水平[MD=-0.41,95%CI(-0.64,-0.18),P<0.001]、空腹血糖水平[MD=-0.51,95%CI(-0.99,-0.02),

P=0.04]方面均优于预混胰岛素,两组比较差异均有统计学意义,而在降低餐后2 h 血糖水平[MD=-0.56,95%CI(-1.21,0.09),

P=0.09]、体质量指数[MD=-0.52,95%CI(-1.52,0.48),P=0.31]方面,差异均无统计学意义;甘精胰岛素组患者的低血糖发生

率[RR=0.65,95%CI(0.46,0.90),P=0.01]低于预混胰岛素组,差异有统计学意义。结论:甘精胰岛素治疗2 型糖尿病的疗效与安

全性优于预混胰岛素。

ABSTRACT:

OBJECTIVE:To systematically review the efficacy and safety of insulin glargine versus premixed insulin in treatment

of type 2 diabetes,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,CJFD,

Wanfang Database and VIP Database,the randomized controlled trials(RCT)about the efficacy and safety of premixed insulin versus

insulin glargine in the treatment of type 2 diabetes were collected. Meta-analysis was performed by using Rev Man 5.0 statistics

software after extracting data and evaluating quality by modified Jadad. RESULTS:A total of 10 RCTs were enrolled,involving 1 655

patients. Results of Meta-analysis showed that insulin glargine was better than premixed insulin on reducing glycated hemoglobin

[M=-0.41,95% CI(-0.64,-0.18),P<0.001] and fasting blood glucose [MD=-0.51,95% CI(-0.99,-0.02),P=0.04],

there were significantly differences between 2 groups,and there were no significantly differences in reducing 2 h postprandial blood

glucose [MD=-0.56,95% CI(-1.21,0.09),P=0.09] and body mass index [MD=-0.52,95% CI(-1.52,0.48),P=0.31];the

incidence of hypoglycemia in insulin glargine group was significantly lower than premixed insulin,there were significantly differences

between 2 groups [RR=0.65,95%CI(0.46,0.90),P=0.01]. CONCLUSIONS:The efficacy and safety of insulin glargine are

better than premixed insulin in the treatment of type 2 diabetes.

期刊: 2016年第27卷第3期
作者: 陈开杰,俞惠翻,房光萃,林越群,陈锦珊
AUTHORS: CHEN Kaijie,YU Huifan,FANG Guangcui,LIN Yuequn,CHEN Jinshan
关键字: 甘精胰岛素;预混胰岛素;2 型糖尿病;Meta分析;疗效;安全性
KEYWORDS: Insulin glargine;Premixed insulin;Type 2 diabetes;Meta-analysis;Efficacy;Safety
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