洛铂/顺铂联合依托泊苷治疗初治小细胞肺癌的疗效和安全性
x

请在关注微信后,向客服人员索取文件

篇名: 洛铂/顺铂联合依托泊苷治疗初治小细胞肺癌的疗效和安全性
TITLE:
摘要:

目的:比较洛铂/顺铂联合依托泊苷治疗初治小细胞肺癌的疗效和安全性。方法:60 例初治小细胞肺癌患者随机均分为

观察组和对照组。观察组患者给予注射用洛铂30 mg/m2,加入5%葡萄糖注射液500 ml 中,d1,静脉滴注1 h+ 依托泊苷注射液100

mg/m2,加入0.9%氯化钠注射液500 ml中,d1~3,静脉滴注1 h。对照组患者给予注射用顺铂25 mg/m2,加入0.9%氯化钠注射液500

ml 中,d1~3,静脉滴注1 h+ 依托泊苷注射液(用法用量同观察组)。两组患者均以3 周为1 个化疗周期。观察两组患者的临床疗效

及毒性反应。结果:两组患者均完成2 个周期以上的治疗。两组患者总有效率比较,差异无统计学意义(P>0.05)。观察组患者恶

心呕吐、腹泻Ⅰ~Ⅳ度总发生率均显著低于对照组,差异均有统计学意义(P<0.05)。结论:洛铂/顺铂联合依托泊苷治疗初治小

细胞肺癌的疗效相当,但在安全性方面洛铂优于顺铂。

ABSTRACT:

OBJECTIVE:To compare the efficacy of lobaplatin / cisplatin combined with etoposide in the treatment of primary

small cell lung cancer. METHODS:60 patients with small cell lung cancer were randomly divided into observation group and control

group. Observation group was given 30 mg/m2 Lobaplatin injection,adding into 500 ml 5% Glucose injection,d1,by intravenous

infusion for 1 h+100 mg/m2 Etoposide injection,adding into 500 ml 0.9% Sodium chloride injection,d1-3,by intravenous infusion

for 1 h. Control group was given 25 mg/m2 Cisplatin injection,adding into 500 ml 0.9% Sodium chloride injection,d1-3,by intravenous

infusion for 1 h+Etoposide injection(the same dose with observation group). 3-week was regarded as a chemotherapy cycle.

The clinical efficacy and toxicities in 2 groups were observed. RESULTS:There were more than 2 cycles for both groups.

There was no significant difference in the total effective rate between 2 groups(P>0.05),and the incidences of nausea,vomiting

and diarrhea in observation group were significantly lower than control group,the differences were statistically significant(P<

0.05). CONCLUSIONS:Lobaplatin / cisplatin combined with etoposide has similar efficacy in the treatment of primary small cell

lung cancer,and lobaplatin has better safety.

期刊: 2016年第27卷第3期
作者: 曹齐生
AUTHORS: CAO Qisheng
关键字: 初治;小细胞肺癌;洛铂;顺铂;肺癌
KEYWORDS: Primary;Small cell lung cancer;Lobaplatin;Cisplatin;Lung cancer
阅读数: 558 次
本月下载数: 6 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!