精准医疗体系下神经内科药学服务模式的探讨与实践
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篇名: 精准医疗体系下神经内科药学服务模式的探讨与实践
TITLE:
摘要: 目的:探讨精准医疗体系下临床药师在神经内科开展药学服务的模式及其所发挥的作用。方法:介绍基因检测技术、群体药动学模型、个体化血药浓度监测等精准化药学手段在神经内科开展药学服务的实践及其作用。结果:临床药师借助基因检测技术,协助临床医师判断氯吡格雷药物的临床疗效,制订华法林的个体给药方案;利用群体药动学预测患者丙戊酸钠的给药剂量;利用血药浓度监测手段制订个体化的用药指导方案,提高临床疗效的同时降低了药品不良反应。结论:精准药学服务可有效地为患者提供最佳的给药方案,预测初始治疗剂量及最佳治疗浓度,提高药物治疗效果、减少药品不良反应。
ABSTRACT: OBJECTIVE: To explore pharmaceutical care model provided by clinical pharmacists in neurology department under precision medicine system and the role of clinical pharmacists. METHODS: The practice and role of precision pharmaceutical care methods in neurology department were introduced, such as gene test technology, population pharmacokinetic model and individual plasma concentration monitoring. RESULTS: By using gene test technology, clinical pharmacists assisted clinical physicians to judge clinical efficacy of clopidogrel and develop individual dosing regimens of warfarin; predicted the dose of sodium valproate by using population pharmacokinetics; formulated individual medication guide by using blood concentration monitoring. Better clinical efficacy had been obtained and ADR reduced. CONCLUSIONS: Precision pharmaceutical care can effectively provide patients with optimal dosing regimens, predict initial dose and optimal therapeutic concentrations, improve efficacy and reduce ADR.
期刊: 2016年第27卷第2期
作者: 黄珊,宋洪涛,林玮玮
AUTHORS: HUANG Shan,SONG Hongtao,LIN Weiwei
关键字: 精准医疗;神经内科;精准药学服务
KEYWORDS: Precision medicine;Neurology department;Precision pharmaceutical care
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