经典名方天王补心丹治疗失眠的研究现状
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篇名: 经典名方天王补心丹治疗失眠的研究现状
TITLE: Research progress of the classic prescription Tianwang buxin dan in the treatment of insomnia
摘要: 天王补心丹作为治疗失眠的经典名方,有片剂、滴丸、贴剂等剂型,临床应用极其广泛。其复方及单味中药可通过调节神经递质、抑制氧化应激反应与炎症因子表达等发挥镇静安神作用。本文以中医理论为基础,结合现代药理学研究对天王补心丹中单味药和其有效成分以及相关药对的镇静安神作用进行综述。结果显示,该方中单味药地黄、酸枣仁、柏子仁、当归、五味子、茯苓和其有效成分以及酸枣仁相关的药对均可不同程度改善失眠症状,除柏子仁的作用机制尚未研究外,其他均主要作用于神经-内分泌-免疫系统,通过调控神经递质、炎症因子和氧化应激发挥镇静催眠作用。
ABSTRACT: Tianwang buxin dan (TWBXD),as a classic prescription for treating insomnia ,in forms of tablet ,drop pill ,patch and others ,has been widely used in clinical practice . Its compound prescription and single ingredient can play a calming and tranquilizing role by regulating neurotransmitters ,inhibiting oxidative stress reaction and the expression of inflammatory factors . Based on the theory of traditional Chinese medicine and combined with modern pharmacological research ,this paper reviews single ingredient and active components of TWBXD ,calming and tranquilizing role of related couplet medicinals . The results showed that the single ingredients such as Rehmannia glutinosa ,the seeds of Zizyphus jujube ,the seeds of Platycladus orientalis ,Angelica sinensis,Schisandra chinensis ,Poria cocos and their effective components as well as related couplet medicinals of Z. jujube could improve the insomnia symptoms in different degrees . Except that the mechanism of the seeds of P. orientalis has not been studied , other ingredients mainly act on nervous -endocrine-immune system . They can play the sedative and hypnotic effects by regulating neurotransmitters,inflammatory factors and oxidation .
期刊: 2022年第33卷第18期
作者: 赵倩,李劲草,黄婷,何芊,李银萍,王萧
AUTHORS: ZHAO Qian,LI Jingcao ,HUANG Ting,HE Qian,LI Yinping ,WANG Xiao
关键字: 天王补心丹;失眠;中医理论基础;药对;药理作用
KEYWORDS: Tianwang buxin dan ; insomnia; theoretical basis of traditional Chinese medicine ; couplet medicinals ;
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