巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用
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篇名: 巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用
TITLE: Application of biomimetic nano drug delivery system of macrophage membrane in disease targeted therapy
摘要: 近年来,基于细胞膜包裹纳米粒的仿生纳米递药系统发展迅速,在多种疾病中表现出比传统纳米递药系统更高的生物相容性及疗效。巨噬细胞作为免疫系统的成员,与多种疾病的发生、发展息息相关。巨噬细胞源自单核细胞,受到相应刺激后,可极化为M1型和M2型:M1型巨噬细胞参与促炎反应,M2型巨噬细胞参与抗炎反应。本文综述了近年来巨噬细胞膜包裹纳米粒的仿生纳米制剂在疾病靶向治疗中的应用现状,结果显示,巨噬细胞膜包裹纳米粒的仿生纳米制剂在恶性肿瘤(乳腺癌、结直肠癌、黑色素瘤、脑胶质瘤)、阿尔茨海默病、肝脏缺血再灌注损伤、动脉粥样硬化等治疗中都显现出了高靶向性和低免疫原性,但目前集中于抗肿瘤研究,且都处于实验室研究阶段。
ABSTRACT: In recent years ,biomimetic nanodelivery system based on cell membrane coating has developed rapidly and shows better biocompatibility and efficacy than traditional nanodelivery systems in a variety of diseases . Macrophages,as members of the immune system ,are closely related to the occurrence and development of a variety of diseases . Macrophages are derived from monocytes and can be polarized into M 1 and M 2 types after corresponding stimulation : M1 macrophages involved in the proinflammatory reaction and M 2 macrophages involved in the inflammatory reaction . This paper reviews the application status of biomimetic nanoparticles coated with macrophage membrane in disease targeted therapy in recent years . Biomimetic nanoparticles coated with macrophage membrane has shown its high targeting and low immunogenicity in the treatment of malignant tumors (breast cancer ,colorectal cancer ,melanoma,glioma),Alzheimer’s disease ,liver ischemia -reperfusion injury ,atherosclerosis and so on . However,the research of Biomimetic nanoparticles coated with macrophage membrane currently focuses on anti -tumor research and is still in the laboratory research stage .
期刊: 2022年第33卷第18期
作者: 李婵莲,宋佳敏,陈美玲,任晓亮,王萌
AUTHORS: LI Chanlian ,SONG Jiamin ,CHEN Meiling ,REN Xiaoliang ,WANG Meng
关键字: 巨噬细胞;细胞膜包裹纳米粒;膜仿生纳米递药系统;靶向治疗
KEYWORDS: macrophage;nanoparticles coated with cell membrane ;biomimetic delivery system ;targeted therapy
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