抗抑郁药物治疗卒中后抑郁系统评价/Meta分析的方法学再评价研究
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篇名: 抗抑郁药物治疗卒中后抑郁系统评价/Meta分析的方法学再评价研究
TITLE: Study on Methodology Re-evaluation for Systematic Review/Meta-analysis of Antidepressants in the Treatment of Post-stroke Depression
摘要: 目的:对已经发表的抗抑郁药物治疗卒中后抑郁的系统评价/Meta分析进行方法学质量再评价。方法:计算机检索Cochrane图书馆、PubMed、Embase、SinoMed、中国知网、万方数据、维普网、中国生物医学文献数据库等数据库,检索时限均为建库起至2019年12月,收集抗抑郁药物治疗卒中后抑郁的系统评价/Meta分析。筛选文献、提取资料后,采用AMSTAR量表评价纳入文献的方法学质量。结果:共纳入33篇系统评价/Meta分析,共523项随机对照试验,涉及41020例患者。AMSTAR方法学质量评分平均得分为6.76分。西酞普兰、度洛西汀、帕罗西汀等对卒中后抑郁治疗有效,但药物间有效性结论并不一致;帕罗西汀不良反应发生率较低;舍曲林和西酞普兰改善患者神经功能缺损情况尚不明确。结论:抗抑郁药物治疗卒中后抑郁的系统评价/Me-ta分析方法学质量中等,且各种药物间的有效性、日常生活能力提高、神经功能恢复等结论存在争议。
ABSTRACT: OBJECTIVE: To re-evaluate t he methodology quality of published systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression. METHODS :Retrieved from Cochrane Library ,PubMed,Embase, SinoMed,CNKI,Wanfang database ,VIP,CBM and other databases ,systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression were collected during the inception to Dec. 2019. After literature screening and data extraction , methodology quality of included literatures were evaluated by using the AMSTAR scale. RESULTS :A total of 33 systematic reviews/Meta-analysis were included ,involving 523 RCTs and 41 020 patients. Average score of AMSTAR methodological quality evaluation was 6.76. Citalopram ,duloxetine and paroxetine were effective for the therapy of post-stroke depression ,but the conclusions about the effectiveness among antide-pressants were not consistents. The ADR incidence of Paroxetine was low. It was not clear that sertraline and citalopram may improve the neurological function of patients. CONCLUSIONS :The methodological quality of systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression is medium ,and the conclusions about the effectiveness of antidepressants ,improvement of daily life ability and the recovery of neurological function are still controversial.
期刊: 2020年第31卷第24期
作者: 关月,郭桂萍,王婧雯,王明明,牟菲,乔逸,李琼阁
AUTHORS: GUAN Yue,GUO Guiping,WANG Jingwen,WANG Mingming,MOU Fei,QIAO Yi,LI Qiongge
关键字: 卒中后抑郁;AMSTAR量表;方法学;质量再评价;系统评价;Meta分析
KEYWORDS: Post-stroke depression ;AMSTAR scale ;Methodology;Quality re-evaluation ;Systematic evaluation ;Meta-analysis
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