左卡尼汀单药治疗男性不育症有效性的Meta分析
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篇名: 左卡尼汀单药治疗男性不育症有效性的Meta分析
TITLE: Effects of L-carnitine Monotherapy in the Treatment of Male Infertility :A Meta-analysis
摘要: 目的:系统评价左卡尼汀单药治疗男性不育症的临床疗效,为临床治疗男性不育症提供循证参考。方法:计算机检索中国知网、万方数据库、维普网、中国生物医学数据库、PubMed、Embase、Cochrane图书馆,检索时限为各数据库建库起至2020年4月12日。收集左卡尼汀单药对比其他化学药单药治疗男性不育症有效性的随机对照试验(RCTs)。对符合纳入标准的文献进行资料提取,并采用改良Jadad标准进行质量评价后,采用RevMan5.3软件进行Meta分析。结果:共纳入8项RCT,合计520例患者。Meta分析结果显示,与其他化学药单药比较,左卡尼汀可显著提高男性不育症患者精液量[MD=0.55,95%CI(0.20,0.91),P=0.002]、精子活动率[MD=1.60,95%CI(0.50,2.69),P=0.004],差异均有统计学意义;在提高精子数量[MD=4.00,95%CI(-3.15,11.15),P=0.27]、前向运动精子百分比[MD=12.58,95%CI(-3.87,29.03),P=0.13]、致女方怀孕率[OR=0.85,95%CI(0.47,1.52),P=0.58]方面,差异均无统计学意义。结论:左卡尼汀单药治疗可显著提高男性不育症患者精液量、精子活动率,但在提高精子数量、前向运动精子百分比、致女方怀孕率方面与其他化学药单药效果相当。
ABSTRACT: OBJECTIVE:To systematically evaluate clinical efficacy of L-carnitine in the treatment of male infertility ,and to provide evidence-based reference for clinical treatment of male infertility. METHODS :Retrieved from CNKI ,Wanfang database , VIP,CBM,PubMed,Embase and the Cochrane library ,randomized controlled trials (RCTs)about L-carnitine and other chemical drugs in the treatment of male infertility were collected during the inception to Apr. 12th,2020. After data extraction of included literatures and quality evaluation with modified Jadad scale ,Meta-analysis was conducted by using RevMan 5.3 software. RESULTS:A total of 8 RCTs were included ,with 520 patients. The results of Meta-analysis showed that compared with other chemical drugs ,L-carnitine could significantly enhance the semen volume [MD=0.55,95%CI(0.20,0.91),P=0.002] and sperm mortality rate [MD=1.60,95%CI(0.50,2.69),P=0.004] of male infertility patients ,with statistical significance. There was no statistical significance in sperm count [MD=4.00,95% CI(-3.15,11.15),P=0.27],the percentage of forward motile sperm [MD=12.58,95%CI(-3.87,29.03),P=0.13],and the percentage of inducing pregnancy rate [OR=0.85,95%CI(0.47,1.52),P= 0.58] of male infertility patients. CONCLUSIONS :L-carnitine can significantly improve the semen volume and sperm mortality of male infertility patients ,and has the same effects as other drugs on improving sperm count ,percentage of forward motile sperm and percentage of inducing pregnancy rate.
期刊: 2020年第31卷第15期
作者: 谢春丽,卢惠,张凌霄,赵星,沈家慧,马燕琳
AUTHORS: XIE Chunli ,LU Hui,ZHANG Lingxiao ,ZHAO Xing,SHEN Jiahui,MA Yanlin
关键字: 左卡尼汀;单药治疗;男性不育症;Meta分析
KEYWORDS: L-carnitine;Monotherapy;Male infertility ;Meta-analysis
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