枳实中酚类化合物的分离与鉴定
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篇名: 枳实中酚类化合物的分离与鉴定
TITLE: Isolation and Identification of Phenols Compounds in Aurantii Fructus Immaturus
摘要: 目的:分离鉴定枳实中的酚类化合物,为其药效物质基础研究提供参考。方法:采用硅胶柱色谱、HW-40F凝胶柱色谱、ODS反相柱色谱以及制备高效液相色谱(HPLC)等方法对枳实中酚类化合物进行分离纯化,并根据其理化性质和波谱数据进行结构鉴定。结果与结论:从枳实中分离鉴定了12个化合物,分别为6′-O-trans-cinnamoyl-3,5-dihydroxyphenylβ-D-glucopyranoside(化合物1)、3-(2′,4′-二羟基苯基)丙酸甲酯(化合物2)、间苯三酚(化合物3)、AurantisideA(化合物4)、5,7,4′-三羟基-8,3′-二甲氧基黄酮-3-O-6″(-3-羟基-3-甲基戊二酸单酯)-β-D-葡萄糖苷(化合物5)、香橙素-7-O-β-D-葡萄糖苷(化合物6)、橙皮素-7-O-β-D-葡萄糖苷(化合物7)、柚皮苷(化合物8)、橙皮苷(化合物9)、芸香柚皮苷(化合物10)、新圣草苷(化合物11)、圣草次苷(化合物12)。其中,化合物1为新化合物,化合物2、3为首次从柑橘属植物中分离得到。
ABSTRACT: OBJECTIVE:To sepa rate and identify the phenols compounds in Aurantii Fructus Immaturus ,and to provide reference for basic research of its effective substances. METHODS :The phenols compounds were isolated and separated by silica gel,HW-40F gel column ,ODS reversed column and preparation HPLC. Their physicochemical properties and spectral data were used to identify the structures. RESULTS & CONCLUSIONS :Totally 12 compounds were isolated from Aurantii Fructus Immaturus,identified as 6′-O-trans- cinnamoyl- 3,5-dihydroxyphenyl β-D-glucopyranoside(compound 1),methyl 3-(2′,4′- dihydroxy phenyl )propionate(compound 2),phloroglucinol(compound 3),aurantiside A (compound 4),5,7,4′-trihydroxy-8, 3′-dimethoxyflavone-3-O-6″-(3-hydroxyl-3-methylglutaroyl) β-D-glucopyranoside (compound 5), aromadendrin-7-O-β-D- glucopyranside(compound 6),hesperidin-7-O-β-D-glucoside(compound 7),naringin(compound 8),hesperidin(compound 9), narirutin (compound 10),neoeriocitrin (compound 11),eriocitrin (compound 12). Among them ,compound 1 is a new compound,and compounds 2 and 3 are isolated from Critus for the first time.
期刊: 2020年第31卷第09期
作者: 邓可众,刘聪,苌美燕,宗琪,熊英
AUTHORS: DENG Kezhong ,LIU Cong,CHANG Meiyan ,ZONG Qi,XIONG Ying
关键字: 枳实;化学成分;酚类化合物;分离;鉴定
KEYWORDS: Aurantii Fructus Immaturus ;Chemical constituents ;Phenols compounds ;Isolation;Identification
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