丹参酮ⅡA磺酸钠对视网膜中央静脉阻塞患者供血及血液流变学
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篇名: 丹参酮ⅡA磺酸钠对视网膜中央静脉阻塞患者供血及血液流变学
TITLE:
摘要:

目的:探讨丹参酮ⅡA磺酸钠对视网膜中央静脉阻塞(CRVO)患者供血情况及血液流变学的影响。方法:92 例CRVO患

者按随机数字表法分为对照组和试验组,各46 例。对照组患者予激光光凝术行常规治疗;试验组患者在常规治疗的基础上加用

丹参酮ⅡA磺酸钠注射液80 mg加入250 ml 0.9%氯化钠注射液中,ivgtt,qd。两组均7 d 为1 个疗程,治疗4 个疗程。比较治疗前后

两组患者视网膜中央动脉(CRA)的血流动力学及血液流变学变化,并观察两组患者眼底荧光血管造影(FFA)和光学相干断层扫

描(OCT)影像。结果:治疗前,两组患者CRA的收缩期最大血流速度(Vmax)、舒张期最小血流速度(Vmin)及阻力指数(RI)比较,差

异无统计学意义(P>0.05);治疗后,两组患者CRA的Vmax、Vmin、RI 均明显改善,且试验组优于对照组,差异有统计学意义(P<

0.05)。治疗后,试验组患者全血高切黏度、全血低切黏度、血浆比黏度和纤维蛋白原定量明显低于对照组,FFA和OCT影像情况

明显优于对照组,差异有统计学意义(P<0.05)。结论:丹参酮ⅡA磺酸钠能够明显改善CRVO患者血流动力学和血液流变学指

标,提高患侧眼部的供血。

ABSTRACT:

OBJECTIVE:To observe the effects of Tanshinone ⅡA sulfonic acid sodium injection on blood supply and blood

rheology of patients with central retinal vein occlusion )CRVO). METHODS:92 CRVO patients were selected and randomly divided

into control group and trial group with 46 cases in each group. Control group was given routine treatment of laser photocoagulation;

trial group was additionally given Tanshinone ⅡA sulfonic acid sodium injection 80 mg added into 0.9% Sodium chloride injection

150 ml,ivgtt,qd. A treatment course of 2 groups lasted for 7 days,and both received 4 courses of treatment. The hemodynamics

and hemorheology of central retinal artery(CRA)were recorded in 2 groups before and after treatment. The fluorescence angiography(

FFA)and optical coherence tomography(OCT)of 2 groups were also observed. RESULTS:Before treatment,there was no

statistically significant difference in Vmax,Vmin and RI of CRA between 2 groups(P>0.05);after treatment,Vmax,Vmin and RI of

CRA in 2 groups were improved significantly,the trial group was better than control group,with statistical significance(P<0.05).

After treatment,whole blood high shear viscosity,whole blood low shear viscosity,plasma specific viscosity and fibrinogen of trial

group were significantly lower than those of control group,and FFA and OCT of trial group were better than those of control group,

with statistical significance(P<0.05). CONCLUSIONS:Tanshinone ⅡA sulfonic acid sodium injection can obviously improve hemodynamics

and hemorheology of CRVO and blood supply and vision of lateral eye.

期刊: 2015年第26卷第35期
作者: 王辉,李晓,黄引谦
AUTHORS: WANG Hui,LI Xiao,HUANG Yin-qian
关键字: 丹参酮ⅡA磺酸钠;视网膜中央静脉阻塞;血流动力学;血液流变学
KEYWORDS: Tanshinone ⅡA sulfonate;Central retinal vein occlusion;Hemodynamics;Hemorheology
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