常温与低温贮存对国产顺式阿曲库铵临床时效的影响
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篇名: 常温与低温贮存对国产顺式阿曲库铵临床时效的影响
TITLE:
摘要:

目的:探讨在常温与低温下贮存国产顺式阿曲库铵对临床时效的影响。方法:90 例择期全麻患者,按随机数字表法分为

低温组、常温A组及常温B组,各30 例。采用TOF-Watch SX肌松监测仪单次超强电刺激观察上肢拇收肌的肌松程度,待患者麻

醉诱导意识消失后静脉注射顺式阿曲库铵0.2 mg/kg,当肌颤搐降到最大抑制程度时行气管插管。低温组患者所用顺式阿曲库铵

置于冰箱2~5 ℃贮存,常温A组与常温B组患者所用顺式阿曲库铵置于30 ℃的恒温箱中分别贮存15 d 和30 d。记录3 组患者起

效时间、肌颤搐最大抑制程度、临床作用时间、恢复指数及总时效。结果:3 组患者在顺式阿曲库铵的作用下肌颤搐的最大抑制程

度均达到0。常温A组和常温B组患者起效时间及临床作用时间与低温组比较,差异均无统计学意义(P>0.05);常温A组和常温

B组患者恢复指数及总时效均长于低温组,差异有统计学意义(P<0.05)。结论:国产顺式阿曲库铵应在低温下贮存,对肌松效应

影响较小。

ABSTRACT:

OBJECTIVE: To observe the effect of room temperature and low temperature storage on the chronergy of domestic

cisatracurium. METHODS:90 patients undergoing elective surgery under general anesthesia were randomly divided into low temperature

group,room temperature A group and room temperature B group,with 30 cases in each groups. Through single supramaximal

electrical stimulation of the adductor pollicis muscle,TOF-Watch SX muscle relaxation monitor was used to observe the degree

of muscle relaxation. After induction of anesthesia and lost consciousness,the patients was given intravenous injection of cisatracurium

0.2 mg/kg;when muscle twitch decreased to the maximum inhibition degree,the patient received endotracheal intubation. The

cisatracurium of low temperature group was stored in refrigerator at 2 to 5 ℃;that of room temperature A group and room temperature

B group was stored in incubator for 15 days or 30 days. The onset time,maximum inhibition degree of muscle twitch,clinical

duration,recovery index and total chronergy were recorded in 3 groups. RESULTS:The maximal inhibition degree of muscle

twitch reached 0 under the action of cisatracurium. There was no statistical significance in onset time and clinical duration between

room temperature A group,room temperature B group and low temperature group(P>0.05);the recovery index and total chronergy

of room temperature A group and room temperature B group were or longer than low temperature group,with statistical significance(

P<0.05). CONCLUSIONS:Domestic cisatracurium stored at low temperature shows weaker effect on muscle relaxation.

期刊: 2015年第26卷第35期
作者: 吕文明,许斌兵
AUTHORS: LYU Wen-ming,XU Bin-bing
关键字: 顺式阿曲库铵;贮存温度;时效;神经肌肉阻滞
KEYWORDS: Cisatracurium;Storage temperature;Chronergy;Neuromuscular blockade
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