我院368 例药品不良反应报告分析
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篇名: 我院368 例药品不良反应报告分析
TITLE:
摘要:

目的:了解我院药品不良反应(ADR)发生的规律及特点,为临床合理用药提供参考。方法:收集郑州人民医院2013-

2014 年上报国家ADR监测中心的368 例ADR报告,从患者性别、年龄、给药途径、ADR涉及的药品种类、ADR累及器官/系统及其

临床表现、ADR转归等方面进行统计、分析。结果:368 例ADR中,女性多于男性(52.99% vs. 47.01%);50 岁以上患者ADR发生

例数最多(占36.14%);引发ADR的药物以抗菌药物、中药制剂居多,分别占40.22%、21.47%;给药途径中静脉注射引发的ADR

最多(占85.60%);临床表现以皮肤及其附件损害最多,其次是消化系统,分别占39.95%、21.47%。所有ADR患者经停用相关药

物后均治愈或好转,无死亡病例。结论:临床应加强ADR监测和分析评价工作,加强抗菌药物和中药注射剂临床使用管理,并采

取各种措施降低药品风险。

ABSTRACT:

OBJECTIVE:To explore regularity and characteristics of ADR in our hospital,and to provide reference for rational

drug use in the clinic. METHODS:A total of 368 ADR collected from Zhengzhou People’s Hospital during 2013-2014 were analyzed

statistically in respects of patient’s gender,age,drug types,route of administration,dosage form,organs or systems involved

in ADR,clinical manifestations,ADR outcome,etc. RESULTS:Of 368 ADR reports,female was more than male

(52.99% vs. 47.01%);the number of patients aged more than 50 years was the most(36.14%);most of ADR cases were induced

by antibiotics and TCM preparations,accounting for 40.22%,21.47%,respectively;among route of administration,most of ADR

cases were induced by intravenous administration(85.60%);main clinical manifestations were lesion of skin and its appendants

(39.95%),followed by digestive system (21.47%). After treatment,all patients were cured or improved,no death case was

found. CONCLUSIONS:Clinic should strengthen ADR monitoring and analysis and evaluarion,strengthen the rational use of antibiotics

and TCM injections and adopt measures to reduce drug risk.

期刊: 2015年第26卷第35期
作者: 刘平,徐国防,刘长缨,李晓苏
AUTHORS: LIU Ping,XU Guo-fang,LIU Chang-ying,LI Xiao-su
关键字: 药品不良反应;合理用药;报告;分析
KEYWORDS: ADR;Rational drug use;Report;Analysis
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