瑶药糯米风醇提物的化学成分研究
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篇名: 瑶药糯米风醇提物的化学成分研究
TITLE:
摘要: 目的:研究瑶药糯米风醇提物的化学成分。方法:采用硅胶柱、SephadexLH-20凝胶柱、AB-8大孔树脂柱等对糯米风75%乙醇提取物的石油醚、乙酸乙酯和正丁醇部位进行分离纯化,根据理化性质和波谱(质谱、氢谱、碳谱)数据分析鉴定所得化合物的结构。结果与结论:从糯米风75%乙醇提取物中共分离鉴定出12个化合物,其中从石油醚部位获得β-谷甾醇(Ⅰ)、豆甾醇(Ⅱ),从乙酸乙酯部位获得对羟基苯甲酸(Ⅲ)、β-胡萝卜苷(Ⅳ)、原儿茶酸(Ⅴ)、6β-羟基-艾里莫芬-7(11)-烯-12,8β-内酯(Ⅵ)、10β-羟基-7(11)-烯-8,12-艾里莫酚内酯(Ⅶ)、10β-羟基-7(11),8(9)-二烯-8,12-艾里莫酚内酯(Ⅷ)、槲皮素(Ⅸ)、金丝桃苷(Ⅹ)、4α-hydroxy-eudesman-11-ene(Ⅺ),从正丁醇部位获得槲皮素-3-O-洋槐糖苷(Ⅻ)。化合物Ⅰ~Ⅻ均为首次从该植物中分离得到。本研究可为糯米风的药理活性研究提供物质基础。
ABSTRACT: OBJECTIVE: To study the chemical constituents of ethanol extract from Yao medicine Cissampelopsis spelaeicola. METHODS: The petroleum ether, ethyl acetate and n-butanol fraction from 75% ethanol extract of C. spelaeicola were isolated and purified by silica gel, SephadexLH-20 gel column and AB-8 macroporous resin column, etc. The structures of the compounds were analyzed and identified by physicochemical properties and spectral data (mass spectrometry, hydrogen spectrum, carbon spectrum). RESULTS & CONCLUSIONS: Twelve compounds were isolated and identified from 75% ethanol extract of C. spelaeicola. β-sitosterol(Ⅰ) and Stigmasterol(Ⅱ) were isolated from petroleum ether fraction; p-hydroxybenzoic acid(Ⅲ), β-daucossterol(Ⅳ), protocatechuic acid(Ⅴ), 6β-hydroxyeremophi-7(11)-en-12,8β-olide(Ⅵ), 10β-hydroxyeremophil-7(11)-en-8,12-olide(Ⅶ), 10β-hydroxyeremophi-7(11),8(9)-dien-8,12-olide(Ⅷ), Quercetin(Ⅸ), Hyperin(Ⅹ) and 4α-hydroxy- eudesman-11-ene(Ⅺ) were isolated from ethyl acetate fraction; quercetin-3-O-robinobioside(Ⅻ) was isolated from n-butanol fraction. Compounds Ⅰ-Ⅻ are isolated from C. spelaeicola for the first time. The study can lay material foundation for activity stady of C. spelaeicola.
期刊: 2019年第30卷第20期
作者: 梁爽,马雯芳,梁可文,赵立春,邓刚,谢冬养
AUTHORS: LIANG Shuang,MA Wenfang,LIANG Kewen,ZHAO Lichun,DENG Gang,XIE Dongyang
关键字: 糯米风;化学成分;分离鉴定;结构鉴定
KEYWORDS: Cissampelopsis spelaeicola; Chemical constituents; Isolation and identification; Structure identification
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