玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎疗效的Meta分析
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篇名: 玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎疗效的Meta分析
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摘要: 目的:系统评价玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎(KOA)的疗效,为临床用药提供循证参考。方法:计算机检索Cochrane 图书馆、PubMed、Embase、Web of Science、中国知网数据库、万方数据库、维普数据库、百度学术数据库,收集玻璃酸钠联合复方倍他米松(观察组)对比玻璃酸钠(对照组)治疗KOA的随机对照试验(RCT)。筛选文献、提取资料后采用Jadad量表对纳入文献质量进行评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入24项RCT,共计2 929例患者。Meta分析结果显示,观察组患者总有效率[OR=5.33,95%CI(3.85,7.38),P<0.000 01]、美国特种外科医院膝关节评分[SMD=1.63,95%CI(1.32,1.93),P<0.000 01]、膝关节功能评分[SMD=1.22,95%CI(0.84,1.59),P<0.000 01]均显著高于对照组,视觉模拟评分[SMD=-1.44,95%CI(-1.76,-1.11),P<0.000 01]显著低于对照组。结论:玻璃酸钠联合复方倍他米松治疗KOA的疗效显著优于单用玻璃酸钠,且能显著改善膝关节功能。
ABSTRACT: OBJECTIVE: To systematically evaluate therapeutic efficacy of sodium hyaluronate combined with Compound betamethasone versus sodium hyaluronate in the treatment of knee osteoarthritis (KOA), and to provide evidence-based reference for clinical drug use. METHODS: Randomized controlled clinical trials (RCTs) about sodium hyaluronate combined with Compound betamethasone (observation group) versus sodium hyaluronate (control group) in the treatment of KOA were collected from Cochrane Library, PubMed, Embase, Web of Science, CNKI, Wanfang database and Baidu academics database, etc. By literature screening, data extraction and quality evaluation of included literatures with Jadad scale, Meta-analysis was carried out by using Rev Man 5.3 software. RESULTS: Totally 24 RCTs were included, involving 2 929 patients. Meta-analysis showed that total response rate [OR=5.33, 95%CI(3.85, 7.38), P<0.000 01], knee joint score of American Special Surgical Hospital [SMD=1.63, 95%CI(1.32, 1.93), P<0.000 01], knee function score [SMD=1.22, 95%CI(0.84, 1.59), P<0.000 01] of the observation group were significantly higher than those of the control group; visual analogue score was significantly lower than that of control group [SMD=-1.44, 95%CI(-1.76,-1.11), P<0.000 01].  CONCLUSIONS: In the treatment of KOA, therapeutic efficacy of sodium hyaluronate combined with Compound betamethasone is significantly better than sodium hyaluronate, and it can significantly improve knee function.
期刊: 2019年第30卷第16期
作者: 宋萍,王小荣,黎一页,林薇薇,朱雪飞,孟志斌
AUTHORS: SONG Ping,WANG Xiaorong,LI Yiye,LIN Weiwei,ZHU Xuefei,MENG Zhibin
关键字: 玻璃酸钠;复方倍他米松;膝关节骨性关节炎;疗效;Meta分析
KEYWORDS: Sodium hyaluronate; Compound betamethasone; Knee osteoarthritis; Therapeutic efficacy; Meta-analysis
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