多指标综合评分结合响应面法优选金卷升板胶囊的超声提取工艺
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篇名: 多指标综合评分结合响应面法优选金卷升板胶囊的超声提取工艺
TITLE:
摘要: 目的:优选金卷升板胶囊的超声提取工艺。方法:以没食子酸、绿原酸、黄芩苷、芦荟大黄素、大黄素甲醚的转移率的综合评分值为考察指标,以乙醇体积分数、超声功率、超声提取时间、液料比为考察因素,在单因素试验基础上采用Box-Behnken响应面法对金卷升板胶囊的超声波提取工艺进行优选,并进行验证试验。结果:最优提取工艺为药材加50倍量的70%乙醇,在超声功率300 W下超声提取40 min。在验证试验中,3批样品提取后没食子酸、绿原酸、黄芩苷、芦荟大黄素、大黄素甲醚的平均转移率分别为85.92%、86.37%、92.76%、90.84%、87.26%(RSD<3.57%,n=3),综合评分平均值为88.95%,与预测值88.27%的相对误差为1.10%。结论:多指标综合评分结合响应面法可用于金卷升板胶囊提取工艺的优选,所得工艺方法简便、结果稳定。
ABSTRACT: OBJECTIVE: To optimize the ultrasonic extraction technology for Jinjuan shengban capsules. METHODS: Using comprehensive score of indexes as transfer rate of gallic acid, chlorogenic acid, baicalin, aloe emodin and emodin methyl ether, with ethanol volume fraction, ultrasonic power, ultrasonic extraction time and liquid-material ratio as factors, the ultrasound extraction technology of Jinjuan shengban capsules was optimized by Box-Behnken response surface methodology based on single factor test. The validation test was conducted. RESULTS: The best extraction technology was 50-fold 70% ethanol, extracting 40 min under 300 W. In validation test, average transfer rates of gallic acid, chlorogenic acid, baicalin, aloe emodin and emodin methyl ether were 85.92%, 86.37%, 92.76%, 90.84% and 87.26% (RSD<3.57%,n=3) in 3 batches of samples; comprehensive score was 88.95%, relative error of which to predicted value of 88.27% was 1.10%. CONCLUSIONS: The response surface method combined with multi-index comprehensive scoring can be used to optimize the extraction technology of Jinjuan shengban capsules which is simple and stable.
期刊: 2019年第30卷第13期
作者: 王玲娇,高先,刘清池,杨继章,孙国祥,于静
AUTHORS: WANG Lingjiao,GAO Xian,LIU Qingchi,YANG Jizhang,SUN Guoxiang,YU Jing
关键字: 金卷升板胶囊;多指标综合评分;响应面法;超声提取;工艺优选
KEYWORDS: Jinjuan shengban capsules; Multi-index comprehensive scoring; Response surface method; Ultrasonic extraction; Optimization of technology
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