注射用七叶皂苷钠治疗术后肿胀疗效和安全性的Meta分析
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篇名: 注射用七叶皂苷钠治疗术后肿胀疗效和安全性的Meta分析
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摘要: 目的:系统评价注射用七叶皂苷钠治疗术后肿胀的疗效和安全性,为临床治疗提供循证参考。方法:计算机检索Cochrane图书馆、PubMed、Web of Science、Embase、中国期刊全文数据库、中国生物医学文献数据库、万方数据库等,纳入常规治疗+注射用七叶皂苷钠(试验组)对比常规治疗+甘露醇或激素等(对照组)治疗术后肿胀的随机对照试验(RCT),提取相关资料并按照Cochrane系统评价员手册 5.1.0评价质量后,采用Rev Man 5.3统计软件对数据进行Meta分析。结果:共纳入12项研究,合计1 615例患者。Meta分析结果显示,试验组患者总有效率[RR=1.23,95%CI(1.15,1.32),P<0.001]、术后肿胀程度评分[MD=-0.62,95%CI(-0.91,-0.33),P<0.001]、术后肿胀时间[MD=-3.65,95%CI(-4.10,-3.20),P<0.001]、术后VAS评分[MD=-1.24,95%CI(-2.06,-0.42),P=0.003]、不良反应发生率[RR=0.39,95%CI(0.17,0.89),P=0.02]均显著优于对照组,差异均有统计学意义;两组患者术后CRP水平比较,差异无统计学意义[MD=-0.92,95%CI(-2.51,0.67),P=0.26]。结论:在常规治疗的基础上给予注射用七叶皂苷钠治疗术后肿胀疗效显著,可降低术后肿胀程度,缩短术后肿胀时间,减轻术后疼痛,且不增加不良反应。
ABSTRACT: OBJECTIVE: To systematically evaluate the efficacy and safety of Sodium aescinate for injection in the treatment of postoperative swelling, and to provide evidence-based reference for the clinical treatment. METHODS: Retrieved from Cochrane Library, PubMed, Web of Science, Embase, CNKI, CBM and Wanfang database, randomized controlled trials (RCTs) about routine treatment+Sodium aescinate for injection (test group) vs. routine treatment+mannitol or hormone (control group) in the treatment of postoperative swelling were collected. After data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0, Meta-analysis was conducted by using Rev Man 5.3 statistical software. RESULTS: Totally 12 studies were included, involving 1 615 patients. Results of Meta-analysis showed that the total response rate [RR=1.23,95%CI(1.15,1.32),P<0.001], postoperative swelling score  [MD=-0.62,95%CI(-0.91,-0.33),P<0.001], swelling time [MD=-3.65,95%CI(-4.10,-3.20),P<0.001], VAS score [MD=-1.24,95%CI(-2.06,-0.42),P=0.003] and the incidence of ADR [RR=0.39,95%CI(0.17,0.89),P=0.02] of trial group were significantly better than those of control group, with statistical significance. There was no statistical significance in the level of CRP between 2 groups after surgery [MD=-0.92,95%CI(-2.51,0.67),P=0.26]. CONCLUSIONS: Based on routine treatment, Sodium aescinate for injection has good efficacy for postoperative swelling, can relieve postoperative swelling, shorten the duration of postoperative swelling and relieve postoperative pain but not increacing ADR.
期刊: 2018年第29卷第14期
作者: 赵新才,杨全军,卢进,郭澄,徐嵘
AUTHORS: ZHAO Xincai,YANG Quanjun,LU Jin,GUO Cheng,XU Rong
关键字: 注射用七叶皂苷钠;术后肿胀;疗效;安全性;Meta分析
KEYWORDS: Sodium aescinate for injection; Postoperative swelling;Efficacy;Safety; Meta-analysis
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