朝药关苍术的化学成分及药理作用研究
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篇名: 朝药关苍术的化学成分及药理作用研究
TITLE:
摘要: 目的:为朝药关苍术的开发与应用提供参考。方法:以“关苍术” “化学成分” “药理作用”“Atractylodes japonica”“Chemical constituents”“Pharmacological effects”等中英文为关键词,利用中国知网、PubMed、ScienceDirect全文文献数据库,对1983-2017年发表的相关文献进行检索,对关苍术的化学成分和药理作用进行论述。结果与结论:截至2017年6月21日,共查阅到相关文献226篇,其中有效文献43篇。关苍术挥发油中主要含有萜类、脂肪族、芳香族等化合物成分,根部还含有糖苷类化合物等有效成分;其主要具有抗炎镇痛、保护心脑血管系统、抗过敏、抗菌、抗病毒、抗溃疡等药理作用。目前为止,对关苍术的化学成分及药理作用的研究已取得初步进展,但有关关苍术的毒性研究报道较少。因此,在研究其药理作用的同时,建议兼顾安全性评价。
ABSTRACT: OBJECTIVE: To provide reference for development and application of Korean medicine Atractylodes japonica. METHODS: Using “Guancangsu” “Huaxue chengfen” “Yaoli zuoyong” “Atractylodes japonica” “Chemical constituents”“Pharmacological effects” as Chinese and English key words, relevant literatures published during 1983-2017 were retrieved from CNKI, PubMed, ScienceDirect full-text database, the chemical constituents and pharmacological effects of A. japonica were reviewed. RESULTS & CONCLUSIONS: As of June 21, 2017, a total of 226 literatures were collected, including 43 valid literatures. A. japonica mainly contains terpenoids, aliphatic, aromatic in volatile oil, glycosides active constituents in roots, and shows anti-inflammatory and analgesic, cardio cerebral vascular protection, contianaphylaxis, antibacterial, antiviral and anti-ulcer effects. Currently, the research of A. japonica on the chemical constituents and pharmacological effects has achieved initial results, however, reports of its toxicity are rare. Therefore, the safety evaluation should be taken into account in the study of its pharmacological effects.
期刊: 2018年第29卷第11期
作者: 李海兰,冯卫军,朴光春,元海丹
AUTHORS: LI Hailan,FENG Weijun,PIAO Guangchun,YUAN Haidan
关键字: 关苍术;化学成分;药理作用
KEYWORDS: Atractylodes japonica; Chemical constituents; Pharmacological effects.
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