丹参-降香油对冠心病心肌缺血血瘀证小型猪血脂及凝血系统的影响
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篇名: 丹参-降香油对冠心病心肌缺血血瘀证小型猪血脂及凝血系统的影响
TITLE:
摘要: 目的:观察丹参-降香油对冠心病心肌缺血血瘀证小型猪血脂及凝血系统的影响。方法:将18只小型猪随机分为假手术组(常规饲料)、模型组(常规饲料)和丹参-降香油组(1 g/kg丹参+0.1 mL/kg降香油,拌食给药) ,连续给药8周。于实验第4周,除假手术组外的其余两组小型猪采用Ameriod缩窄环植入法建立冠心病心肌缺血血瘀证模型,第8周时结合冠状动脉造影和宏观体征观察以确立模型成功。分别于实验第2、6、8周前腔静脉取血检测小型猪血清中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(apoA1)、apoB水平和凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)以及纤维蛋白原(FIB)水平。结果:于实验第6、8周,与假手术组比较,模型组小型猪血清中TC、TG、LDL-C、apoB和FIB水平升高,PT、APTT、TT缩短,HDL-C和apoA1水平降低,差异均有统计学意义(P<0.05或P<0.01);与模型组比较,丹参-降香油组小型猪血清中TC、TG、LDL-C、apoB和FIB水平降低,PT、APTT和TT延长,HDL-C和apoA1水平升高,差异均有统计学意义(P<0.05 或P<0.01)。结论:丹参-降香油对冠心病心肌缺血血瘀证小型猪具有降脂作用,并能改善血液凝血系统指标的异常。
ABSTRACT: OBJECTIVE: To observe the effects of Salvia miltiorrhiza-volatile oil of Dalbergia odorifera on blood lipid and blood coagulation system in coronary heart disease myocardial ischemia miniature swine with blood stasis syndrome. METHODS: A total of 18 swine were randomly divided into sham operation group (routine feed), model group (routine feed) and S. miltiorrhiza-volatile oil of D. odorifera group (1 g/kg S. miltiorrhiza+0.1 mL/kg oil of D. odorifera, mixing administration), for consecutive 8 weeks. At 4th week, coronary heart disease myocardial ischemia model of blood stasis syndrome was established by Ameriod coarctation ring implantation in other 2 groups except for sham operation group. At 8th week, the syndrome of the model was observed according to coronary angiography and the macroscopic indications. At 2th, 6th, 8th week, intravenous blood was collected to test the serum levels of TC, TG, LDL-C, HDL-C, apolipoprotein A1 (apoA1), apoB, PT, APTT, TT and FIB in miniature swine. RESULTS: At 6th, 8th week, compared with sham operation group, serum levels of TC, TG, LDL-C, apoB and FIB were increased in model group, while PT, APTT and TT were shortened and the levels of HDL-C and apoA1 were decreased, with statistical significance (P<0.05 or P<0.01). Compared with model group, the serum levels of TC,TG, LDL-C and apoB were decreased in S. miltiorrhiza-volatile oil of D. odorifera group, while PT, APTT and TT were prolonged and the levels of HDL-C and apoA1 were increased, with statistical significance (P<0.05 or P<0.01). CONCLUSIONS: The S. miltiorrhiza-volatile oil of D. odorifera could reduce blood lipid and improve blood coagulation system index disorder in coronary heart disease myocardial ischemia miniature swine with blood stasis syndrome.
期刊: 2018年第29卷第9期
作者: 蔺瑞,段佳林,牟菲,赵美娜,李飞,苏晶,文爱东,奚苗苗
AUTHORS: LIN Rui,DUAN Jialin,MU Fei,ZHAO Meina,LI Fei,SU Jing,WEN Aidong,XI Miaomiao
关键字: 丹参;降香油;冠心病;心肌缺血;血瘀证;小型猪;血脂;凝血系统
KEYWORDS: Salvia miltiorrhiza; Volatile oil of Dalbergia odorifera; Coronary heart disease; Myocardial ischemia; Blood stasis syndrome; Miniature swine; Blood lipid; Coagulation system
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