玉屏风颗粒对变应性鼻炎合并支气管哮喘患儿免疫功能及相关指标的影响
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篇名: 玉屏风颗粒对变应性鼻炎合并支气管哮喘患儿免疫功能及相关指标的影响
TITLE:
摘要: 目的 :探讨玉屏风颗粒对变应性鼻炎(AR)合并支气管哮喘(BA)患儿免疫功能及相关指标的影响。方法:回顾性分析2014年2月-2017年9月101例AR合并BA患儿的资料,按治疗方案的不同分为对照组(47例)和观察组(54例)。对照组患儿经口吸入沙美特罗替卡松粉吸入剂1吸,每日2次+每侧鼻孔喷糠酸莫米松鼻喷雾剂50 μg;观察组患儿在对照组治疗的基础上口服玉屏风颗粒5 g,每日3次,连用2周、后停药2周,循环3次。两组患儿均连续治疗3个月。观察两组患儿治疗前后临床症状及体征评分、T淋巴细胞亚群(CD4+、CD8+、CD4+/CD8+)、血清白细胞介素4(IL-4)、γ干扰素(IFN-γ)、特异性免疫球蛋白E(IgE)水平及不良反应发生情况。结果:治疗前,两组患儿临床症状及体征评分、T淋巴细胞亚群、血清IL-4、IFN-γ、IgE水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患儿临床症状及体征评分、CD4+、CD4+/CD8+、血清IL-4、IgE水平均显著低于同组治疗前,且观察组显著低于对照组;两组患儿CD8+、血清IFN-γ水平均显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:玉屏风颗粒可有效改善AR合并BA患儿的免疫功能,缓解临床症状,且不增加不良反应的发生。
ABSTRACT: OBJECTIVE: To investigate the effects of Yupingfeng granules on immune function and related indexes of children with allergic rhinitis (AR) complicated with bronchial asthma (BA). METHODS: Clinical information of 101 children with AR complicated with BA during Feb. 2014-Sept. 2017 were analyzed retrospectively, and they were divided into control group (47 cases) and observation group (54 cases) according to treatment plan. Control group was given Salmeterol xinafoate and fluticasone propionate powder for inhalation through mouth, one inhalation, twice a day+Mometasone furoate nasal spray 50 μg each nostril. Observation group was additionally given Yupingfeng granules 5 g orally, 3 times a day, for consecutive 2 weeks, drug withdrawal at 2 weeks interval, recycled 3 times. Both groups received treatment for consecutive 3 months. Clinical symptom and sign scores, the levels of T-lymphocyte subgroup (CD4+, CD8+, CD4+/CD8+), IL-4, IFN-γ and IgE before and after treatment, the occurrence of ADR were observed in 2 groups. RESULTS: Before treatment, there was no statistical significance in clinical symptom and sign scores, levels of T-lymphocyte subgroup, serum levels of IL-4, IFN-γ or IgE between 2 groups (P>0.05). After treatment, clinical symptom and sign scores, CD4+, CD4+/CD8+, serum levels of IL-4 and IgE in 2 groups were all significantly lower than before treatment; observation group was significantly lower than control group. CD8+ and serum levels of IFN-γ in 2 groups after treatment were significantly higher than before treatment; observation group was significantly higher than control group, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS: Yupingfeng granules can effectively improve immune function of children with AR complicated with BA, and relieve clinical symptom without increasing the occurrence of ADR.
期刊: 2018年第29卷第4期
作者: 白尚杰,梁莎,鲁晓军
AUTHORS: BAI Shangjie,LIANG Sha,LU Xiaojun
关键字: 玉屏风颗粒;沙美特罗替卡松;莫米松;变应性鼻炎;支气管哮喘;免疫功能;安全性
KEYWORDS: Yupingfeng granules; Salmeterol xinafoate and fluticasone propionate; Mometasone; Allergic rhinitis; Bronchial asthma; Immune function; Safety
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