芒柄花素包合物脂质体的制备及质量评价
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篇名: 芒柄花素包合物脂质体的制备及质量评价
TITLE:
摘要: 目的:制备芒柄花素(FMN)包合物脂质体,并评价其质量。方法:以薄膜分散法制备FMN包合物脂质体,考察所制脂质体的外观形态、粒径、Zeta电位、包封率以及体外释放行为。结果:所制FMN包合物脂质体的粒径为(255.34±12.87) nm、Zeta电位为(25.32±3.51) mV、包封率为(81.63±0.79)%(n=3)、24 h的累积释放度为56.12%。结论:本方法成功制得具有良好缓释效果的FMN包合物脂质体,且质量符合相关标准。
ABSTRACT: OBJECTIVE: To prepare Formononetin (FMN) inclusion compound liposome and evaluate its quality. METHODS: FMN inclusion compound liposome was prepared by film dispersion method. The morphology, particle size, Zeta potential, encapsulation efficiency and in vitro release properties were studied. RESULTS: The particle size, Zeta potential and encapsulation efficiency of prepared FMN inclusion compound liposome were (255.34±12.87) nm, (25.32±3.51) mV, (81.63±0.79)%, respectively (n=3). The 24 h accumulative release rate of prepared FMN inclusion compound liposome was 56.12%. CONCLUSIONS: FMN inclusion compound liposome with good sustained-release effect is prepared successfully and in line with related quality standard.
期刊: 2018年第29卷第3期
作者: 廖灿城,郭波红,许丹翘,吴秀君,易军,黄泽贤
AUTHORS: LIAO Cancheng,GUO Bohong,XU Danqiao,WU Xiujun,YI Jun,HUANG Zexian
关键字: 芒柄花素;包合物;脂质体;质量评价
KEYWORDS: Formononetin; Inclusion compound; Liposome; Quality evaluation
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