丙基硫氧嘧啶致相关性小血管炎118例文献分析
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篇名: 丙基硫氧嘧啶致相关性小血管炎118例文献分析
TITLE:
摘要: 目的:探讨丙基硫氧嘧啶(PTU)诱发相关性小血管炎(ASV)的一般规律及特点,为临床合理用药提供参考。方法:检索1990-2016年发表的PTU诱发ASV不良反应/不良事件的个案报告,并就收集到的118例ADR相关信息进行统计和分析。结果:PTU诱发ASV女性发生率较高,且以18~59 岁最高;87例患者用药剂量在600 mg/d内,用药后1~5 年发生率较高;临床表现以肾、肺系统损害较多;所有患者停药后59例行激素治疗,30例行激素联合免疫抑制剂治疗;115例患者预后良好,3例死亡。结论:对使用PTU的患者除定期筛查抗中性粒细胞胞浆抗体外,还应定期评估其不良反应症状,以减少或避免严重不良反应的发生。
ABSTRACT: OBJECTIVE: To investigate the general regularity and characteristics of propylthiouracil (PTU)-associated small vasculitis (ASV), and to provide reference for rational drug use in the clinic. METHODS: ADR/ADE case reports of PTU-ASV published during 1990-2016 were retrieved. The data of 118 ADR cases were analyzed statistically. RESULTS: The incidence of PTU-ASV was higher in female and was highest in 18-59 age group. Drug dose of 87 patients were within 600 mg/d, and the incidence of PTU-ASV was the highest within 1-5 years after medication. Main clinical manifestations were renal and lung function injury. After drug withdrawal, 59 patients received hormone therapy, and 30 patients received hormone combined immunosuppressive agent. Finally,115 patients were recovered and 3 patients died. CONCLUSIONS: In older to reduce or avoid the occurrence of ADR, it is necessary to regularly check antineutrophil cytoplasmic antibody related indexes and evaluate the symptoms of ADR.
期刊: 2017年第28卷第33期
作者: 田晓江,唐学文,季欢欢,贾运涛
AUTHORS: TIAN Xiaojiang,TANG Xuewen,JI Huanhuan,JIA Yuntao
关键字: 丙基硫氧嘧啶;相关性小血管炎;不良反应;文献分析
KEYWORDS: Propylthiouracil; Associated small vasculitis; ADR; Literature analysis
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