Box-Behnken设计-响应面法优化桂枝茯苓胶囊的闪式提取工艺
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篇名: Box-Behnken设计-响应面法优化桂枝茯苓胶囊的闪式提取工艺
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摘要: 目的:优化桂枝茯苓胶囊的闪式提取工艺。方法:以内刃转速、液固比、提取时间等为考察因素,以没食子酸、芍药苷、苯甲酸、肉桂酸、苯甲酰芍药苷、苦杏仁苷转移率的综合评价值为考察指标,在单因素试验基础上结合Box-Behnken设计-响应面法对桂枝茯苓胶囊闪式提取工艺进行优化;进行验证试验,并与常规的煎煮提取法(提取2次,共用时240 min)进行效果比较。结果:闪式提取桂枝茯苓胶囊的最优工艺为以水为提取溶剂,内刃转速5 600 r/min,液固比10.5 ∶ 1,提取时间60 s。在此条件下验证试验的平均综合评价值为85.40%(n=3),与预测值85.55%的相对误差为0.15%,并高于煎煮提取法(72.65%)。结论:优化的闪式提取工艺用于桂枝茯苓胶囊的提取,具有高效、快速的特点。
ABSTRACT: OBJECTIVE: To optimize the flash extraction technology for Guizhi fuling capsule. METHODS: Using blade speed, liquid-solid ratio, extraction time as investigation factors, using the comprehensive evaluation values consisting of transfer rates of gallic acid, paeoniflorin, benzoic acid, cinnamic acid, benzoyl paeoniflorin, amygdalin as investigation index, single factor test was combined with Box-Behnken design-response surface method to optimize the flash extraction technology for Guizhi fuling capsule. Verification test was conducted and compared with conventional decoction extraction method (extracting twice, totally 240 min). RESULTS: The optimal flash extraction technology for Guizhi fuling capsule was using water as extraction solvent with blade speed of 5 600 r/min and liquid-solid ratio of 10.5 ∶ 1, extracting for 60 s. The average comprehensive evaluation value of verification test was 85.40% (n=3), with relative error of 0.15% to the predicted value (85.55%), higher than decoction extraction method (72.65%). CONCLUSIONS: Optimized flash extraction technology for Guizhi fuling capsule is efficient and rapid.
期刊: 2017年第28卷第31期
作者: 王正宽,刘圆,石晓朦,王振中,萧伟
AUTHORS: WANG Zhengkuan,LIU Yuan,SHI Xiaomeng,WANG Zhenzhong,XIAO Wei
关键字: 桂枝茯苓胶囊;单因素试验;Box-Behnken设计;响应面法;闪式提取;工艺优化
KEYWORDS: Guizhi fuling capsule; Single factor test; Box-Behnken design; Response surface method; Flash extraction; Technology extraction
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