加味玉屏风散汤剂治疗老年2型糖尿病多汗症患者的临床观察
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篇名: 加味玉屏风散汤剂治疗老年2型糖尿病多汗症患者的临床观察
TITLE:
摘要: 目的:观察加味玉屏风散汤剂治疗老年2型糖尿病多汗症患者的临床疗效及安全性。方法:选取2015年1月-2016年6月我院门诊诊治的老年2型糖尿病多汗症患者120例,按随机数字表法分为对照组和观察组,各60例。对照组患者给予糖尿病常规化学药物治疗;观察组患者在对照组基础上加用加味玉屏风散,以水煎制,每次300 mL,早晚各服150 mL,均于餐前1 h服用。两组患者疗程均为1个月。比较两组患者治疗前后的血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)]和中医症状评分,观察临床疗效和不良反应发生情况。结果:治疗前,两组患者的FPG、2 hPG、HbA1c和中医症状评分比较,差异均无统计学意义(P>0.05)。治疗后,两组患者的FPG、2 hPG、HbA1c和中医症状评分均较治疗前明显降低,且观察组FPG、HbA1c和中医症状评分明显低于对照组,差异均有统计学意义(P<0.05);但两组患者2 hPG比较,差异无统计学意义(P>0.05)。观察组患者的总有效率(90.00%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:加味玉屏风散汤剂治疗老年2型糖尿病多汗症能有效改善患者临床症状,疗效较好且安全性较高。
ABSTRACT: OBJECTIVE: To observe clinical efficacy and safety of Modified yupingfeng powder decoction in the treatment of elderly patients with type 2 diabetes hyperhidrosis. METHODS: A total of 120 elderly patients with type 2 diabetes hyperhidrosis selected from outpatient of our hospital during Jan. 2015 to Jun. 2016 were divided into control group and observation group according to random number table, with 60 cases in each group. Control group was given routine chemical drug therapy of diabetes. Observation group was additionally given Modified yupingfeng powder, decocted with water, 300 mL each time, 150 mL morning and night, 1 h before meal, on the basis of control group. Treatment courses of 2 groups both were 1 month. Blood glucose indexes (FPG, 2 hPG, HbA1c) and TCM symptom scores before and after treatment were compared between 2 groups. Clinical efficacies and the occurrence of ADR were observed. RESULTS: Before treatment, there was no statistical significance in FPG, 2 hPG, HbA1c or TCM symptom scores between 2 groups (P>0.05). Compared to before treatment, FPG,2 hPG, HbA1c and TCM symptom scores of 2 groups were decreased significantly after treatment; the levels of FPG, HbA1c and TCM symptom score in observation group were significantly lower than control group, with statistical significance (P<0.05). But there was no statistical significance in 2 hPG between 2 groups (P>0.05). Total response rate of observation group (90.00%) was significantly higher than that of control group (70.00%), with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS: Modified yupingfeng powder decoction can effectively improve the clinical symptoms, and shows good therapeutic efficacy and safety for elderly patients with type 2 diabetes hyperhidrosis.
期刊: 2017年第28卷第29期
作者: 尹冬,惠媛
AUTHORS: YIN Dong,HUI Yuan
关键字: 2型糖尿病;糖尿病多汗症;老年患者;加味玉屏风散;中医症状
KEYWORDS: Type 2 diabetes; Diabetes hyperhidrosis; Elderly patients; Modified yupingfeng powder; TCM symptoms
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