某院门诊高血压合并冠心病患者应用ACEI/ARB类药物的相关因素研究
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篇名: 某院门诊高血压合并冠心病患者应用ACEI/ARB类药物的相关因素研究
TITLE:
摘要: 目的:探究高血压合并冠心病患者应用血管紧张素转换酶抑制剂(ACEI)/血管紧张素受体阻滞药(ARB)类药物的相关因素。方法:选取2012年1月-2015年1月于某院就诊治疗的600例高血压合并冠心病患者,其中服用ACEI/ARB类药物的310例为观察组,未服用该类药物的290例为对照组。收集两组患者基本信息与实验室检查指标进行分析。结果:观察组与对照组患者动态动脉硬化指数[(0.57±0.13)、(0.40±0.11)]、24 h平均收缩压[(146.42±11.24)、(132.31±9.85) mmHg]、24 h平均舒张压[(78.14±9.21)、(82.79±8.33)mmHg]、24 h动态脉压[(64.89±13.57)、(53.54±9.78)mmHg]、饮酒率(58.71%、28.28%)、中等强度运动率(31.29%、65.17%)、体质量指数[(33.28±2.07)、(23.17±2.86)kg/m2]、左室射血分数(LVEF)[(35.65±11.42)%、(48.01±12.45)%]、血脂异常率(66.77%、30.34%)、心肌梗死率(68.39%、39.66%)、血运重建率(69.68%、33.10%)、冠心病病程等比较,差异均有统计学意义(P<0.05)。将冠心病病程、血脂异常、心肌梗死、血运重建情况进行多因素Logistic 回归分析,差异均有统计学意义(P<0.05)。结论:高血压合并冠心病患者应用ACEI/ARB类药物受多种因素的影响,血脂异常、心肌梗死、血运重建是独立影响因素且呈正相关,但随着病程增加药物使用率会下降。
ABSTRACT: OBJECTIVE: To study related factors of ACEI/ARB drugs in hypertension patients with coronary heart disease. METHODS: Six hundred hypertension patients with coronary heart disease were selected from a hospital during Jan. 2012-Jan. 2015, 310 patients receiving ACEI/ARB drugs were included in observation group, and 290 patients not receiving these drugs were included in control group. General information and lab indexes of 2 groups were collected and analyzed. RESULTS: There were statistical significances in ambulatory arterial stiffness indexes [(0.57±0.13),(0.40±0.11)], 24 h average systolic blood pressure [(146.42±11.24)mmHg, (132.31±9.85)mmHg], 24 h average diastolic blood pressure [(78.14±9.21)mmHg, (82.79±8.33)mmHg], 24 h ambulatory pulse pressure [(64.89±13.57)mmHg,(53.54±9.78)mmHg], drinking rate (58.71%, 28.28%), moderate intensity rate (31.29%, 65.17%), BMI[(33.28±2.07)kg/m2,(23.17±2.86)kg/m2], LVEF [(35.65±11.42)%, (48.01±12.45)%], dyslipidemia rate (66.77%, 30.34%), myocardial infarction rate (68.39%, 39.66%), revascularization rate (69.68%, 33.10%) and duration of coronary heart disease between 2 groups (P<0.05). The duration of coronary heart disease, dyslipidemia, myocardial infarction, revascularization were included in multivariate Logistic regression analysis, with statistical significance (P<0.05). CONCLUSIONS: The application of ACEI/ARB drugs in hypertension patients complicated with coronary heart disease is influenced by many factors; dyslipidemia, myocardial infarction and revascularization are positive independent influential factors of ACEI/ARB drug use in the treatment, but drug use rate will decline with the duration increase.
期刊: 2017年第28卷第23期
作者: 郭军,皇甫丰田,唐龙骞
AUTHORS: GUO Jun,HUANGFU Fengtian,TANG Longqian
关键字: 血管紧张素转换酶抑制剂;血管紧张素受体阻滞药;高血压;冠心病
KEYWORDS: ACEI; ARB; Hypertension; Coronary heart disease
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