氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的临床观察
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篇名: 氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的临床观察
TITLE:
摘要: 目的:观察氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的疗效和安全性。方法:72例急性偏头痛患者随机分为对照组(36例)和观察组(36例)。在常规治疗的基础上,对照组患者口服盐酸氟桂利嗪胶囊,65岁及以下每晚10 mg,每日1次,65岁以上每晚5 mg,每日1次;观察组患者在对照组治疗的基础上给予注射用丹参多酚酸盐200 mg,静脉滴注,每日1次。两组均连续治疗至痊愈或连续治疗2周。观察两组患者的临床疗效、起效时间、痊愈时间,治疗前后视觉模拟疼痛 (VAS) 评分、发作频率和持续时间及不良反应发生情况。结果:治疗过程中两组均无患者终止、脱落,均完成治疗。观察组患者总有效率(97.22%)显著高于对照组(86.11%),起效时间、痊愈时间均显著短于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者VAS评分、发作频率、持续时间比较,差异均无统计学意义(P>0.05)。治疗后,两组患者VAS评分、发作频率、持续时间均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,氟桂利嗪联合丹参多酚酸盐治疗急性偏头痛的疗效与安全性均较好。
ABSTRACT: OBJECTIVE: To observe the clinical efficacy and safety of flunarizine combined with salvianolate in the treatment of acute migraine. METHODS: A total of 72 patients with acute migraine were randomly divided into control group (36 cases) and observation group (36 cases). Based on routine treatment,control group was given Flunarizine hydrochloride capsules orally, 10 mg for 65 year-old and below once a day, 5 mg for more than 65 year-old once a day. Observation group was additionally given Flunarizine hydrochloride for injection 200 mg intravenously, once a day, on the basis of control group. Both groups were treated contineously till cured or for 2 weeks. Clinical efficacy, onset time, recovery time, VAS score, frequency and duration of headache attack, ADR were observed in 2 groups. RESULTS: In the course of treatment, the two groups did not terminate and fall off, and all of them completed the treatment. The total response rate (97.22%) of observation group was significantly higher than that (86.11%) of control group; onset time and recovery time of observation group were both shorter than those of control group, with statistical significance (P<0.05). Before treatment, there was no statistical significance in VAS score, frequency or duration of headache attack between 2 groups (P>0.05). After treatment, VAS score, frequency and duration of headache attack in 2 groups were all significantly lower than before, and the observation group was significantly lower than the control group, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS: Based on routine treatment,flunarizine hydrochloride capsules combined with Salvianolate injection show significant efficacy for acute migraine with good safety.
期刊: 2017年第28卷第21期
作者: 王娟,申文娟,姚旭,郑自通,邓珊珊
AUTHORS: WANG Juan,SHEN Wenjuan,YAO Xu,ZHENG Zitong,DENG Shanshan
关键字: 氟桂利嗪;丹参多酚酸盐;急性偏头痛;疗效;安全性
KEYWORDS: Flunarizine;Salvianolate;Acute migraine;Therapeutic efficacy; Safety
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