某院2013-2015年813例ADR报告分析
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篇名: 某院2013-2015年813例ADR报告分析
TITLE:
摘要: 目的:了解某三级甲等医院药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:对该院2013-2015年上报至国家ADR监测中心的813例ADR报告,按照患者年龄、性别、给药途径、药品种类、ADR累及器官/系统及临床表现、转归等进行回顾性分析。结果:813例ADR报告中,男性391例(48.09%),女性422例(51.91%);60岁以上的患者为ADR高发人群,有347例(42.68%);以静脉给药途径引发ADR最多,有747例(91.88%);药品种类中抗感染药引起的ADR例数最多,有382例(46.99%),其中头孢菌素类占比最高,为38.22%(146例);ADR累及器官/系统以皮肤及其附件为主,有434例(53.38%)。结论:对于静脉给药、使用抗感染药的老年患者应加强ADR监测,以减少ADR的发生,保证用药安全。
ABSTRACT: OBJECTIVE: To investigate the characteristics and regularity of adverse drug reaction (ADR) in a third grade class A hospital, and to provide reference for rational drug use in clinic. METHODS: A total of 813 cases of ADR reported to National ADR Monitoring by the hospital during 2013-2015 were summarized and analyzed retrospectively in terms of age, gender, route of administration, drug type, organs or systems involved in ADR, clinical manifestation and outcome. RESULTS: Among 813 cases of ADR, there were 391 male (48.09%) and 422 female (51.91%). Patients aged more than 60 were with high incidence of ADR, involving 347 cases (42.68%). Among routes of administration, most ADR cases were caused by intravenous administration, involving 747 cases (91.88%). Among all drug types, the number of ADR cases caused by anti-infective drugs was the most, involving 382 cases (46.99%); cephalosporins took up the highest proportion, being 38.22% (146 cases). Organs or systems involved in ADR were mainly skin and its appendants, involving 434 cases (53.38%). CONCLUSIONS: ADR monitoring should be strengthened for elderly patients receiving anti-infective drugs intravenously so as to reduce the occurrence of ADR and guarantee medication safety.
期刊: 2017年第28卷第17期
作者: 吴迪,王真
AUTHORS: WU Di,WANG Zhen
关键字: 药品不良反应;用药安全;合理用药
KEYWORDS: ADR; Medication safety; Rational drug use
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