独活寄生汤联合硫酸氨基葡萄糖治疗膝骨性关节炎的临床观察
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篇名: 独活寄生汤联合硫酸氨基葡萄糖治疗膝骨性关节炎的临床观察
TITLE:
摘要: 目的:观察独活寄生汤联合硫酸氨基葡萄糖对膝骨性关节炎的疗效及安全性。方法:  选取我院2015年12月-2016年4月收治的膝骨性关节炎患者86例,按照随机数字表法分为试验组和对照组,各43例。对照组患者给予硫酸氨基葡萄糖片1~2片,po(餐时),tid;试验组在此基础上给予独活寄生汤1剂,以水煎成200 mL,分早晚两次服用。两组患者均治疗28 d。观察两组患者临床疗效,血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6水平,关节液基质金属蛋白酶(MMP)-3、MMP-9和MMP-13水平,并记录治疗过程中不良反应发生情况。结果:治疗前,两组患者hs-CRP、TNF-α、IL-6、MMP-3、MMP-9和MMP-13水平比较,差异均无统计学意义(P>0.05)。治疗后,试验组患者总有效率(95.3%)明显高于对照组(76.7%),差异有统计学意义(P<0.05)。试验组患者hs-CRP水平明显降低,两组患者血清TNF-α、IL-6水平及关节液MMP-3、MMP-9、MMP-13水平均明显下降,且试验组患者上述指标水平均明显低于对照组,差异均有统计学意义(P<0.05)。试验组患者不良反应发生率(7.0%)明显低于对照组(46.5%),差异有统计学意义(P<0.05)。结论:独活寄生汤联合硫酸氨基葡萄糖治疗膝骨性关节炎疗效显著,且安全性较高。
ABSTRACT: OBJECTIVE: To observe therapeutic efficacy and safety of Duhuo jisheng decoction combined with glucosamine gulfate for genual osteoarthritis. METHODS: Totally 86 patients with genual osteoarthritis selected from our hospital during Dec. 2015-Apr. 2016 were divided into trial group and control group according to random number table, with 43 cases in each group. Control group was given Glucosamine sulfate tablets 1-2 tablet, po (at mealtime), tid. Trial group was additionally given Duhuo jisheng decoction, one dose a day, decocting 200 mL with water, morning and evening at twice, on the basis of control group. Both groups received treatment for 28 d. Clinical efficacies of 2 groups were observed as well as the levels of hs-CRP, TNF-α, IL-6, MMP-3, MMP-9 and MMP-13. The occurrence of ADR was recorded during treatment. RESULTS: Before treatment, there was no statistical significance in hs-CRP, TNF-α, IL-6, MMP-3, MMP-9 and MMP-13 between 2 groups (P>0.05). After treatment, total response rate of trial group (95.3%) was significantly higher than that of control group (76.7%), with statistical significance (P<0.05). The level of hs-CRP in trial group was significantly lowered, and the levels of TNF-α and IL-6, MMP-3, MMP-9, MMP-13 in 2 groups were decreased significantly; above indexes of trial group were significantly lower than those of control group, with statistcal significance (P<0.05). The incidence of ADR in trial group (7.0%) was significantly lower than control group (46.5%), with statistical significance (P<0.05). CONCLUSIONS: Duhuo jisheng decoction combined with glucosamine gulfate shows good therapeutic efficacy for genual osteoarthritis with good safety.
期刊: 2017年第28卷第14期
作者: 李建,樊炜骏,孙鹏
AUTHORS: LI Jian,FAN Weijun,SUN Peng
关键字: 膝骨性关节炎;独活寄生汤;肿瘤坏死因子α;白细胞介素-6;基质金属蛋白酶
KEYWORDS: Genual osteoarthritis; Duhuo jisheng decoction; TNF-α; IL-6; MMP
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