系统评价血必净注射液对重症急性胰腺炎患者炎症因子的影响
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篇名: 系统评价血必净注射液对重症急性胰腺炎患者炎症因子的影响
TITLE:
摘要: 目的:系统评价血必净注射液对重症急性胰腺炎(SAP)患者炎症因子的影响,为临床提供循证参考。方法:计算机检索PubMed、中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊数据库和万方数据库,收集血必净注射液对SAP患者炎症因子影响的随机对照试验(RCT),提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.2 统计软件进行Meta 分析。结果:共纳入10项RCT,合计811例患者。Meta 分析结果显示,血必净注射液能显著降低SAP患者白细胞介素(IL)-1水平[SMD=1.22,95%CI(0.64,1.79),P<0.001]、IL-6水平[SMD=1.86,95%CI(1.46,2.27),P<0.001]、IL-8水平[SMD=2.16,95%CI(1.45,2.88),P<0.001]、肿瘤坏死因子水平[SMD=2.16,95%CI(1.56,2.76),P<0.001]、C反应蛋白水平[SMD=1.63,95%CI(0.56,2.70),P<0.001]和内毒素水平[SMD=2.39,95%CI(1.33,3.45),P<0.001],还能显著提高SAP患者IL-10水平[SMD=-2.75,95%CI(-3.84,-1.67),P<0.001],差异均有统计学意义。结论:在常规治疗的基础上,血必净注射液可以显著改善SAP患者各种炎症因子水平。
ABSTRACT: OBJECTIVE: To systematically review the effect of Xuebijing injection on inflammatory mediators in patients with severe acute pancreatitis (SAP), and provide evidence-based reference for clinic. METHODS: Retreived from PubMed、CJFD, CBM, VIP and Wanfang Database, randomized controlled trials (RCT) about the effect of Xuebijing injection on inflammatory mediators in patients with SAP were collected. Meta-analysis was performed by using Rev Man 5.2 software after data extraction and bias risk evaluation. RESULTS: Totally 10 RCTs, involving 811 patients. Results of Met-analysis showed, Xuebijing injection can significantly reduce IL-1[SMD=1.22,95%CI(0.64,1.79),P<0.001],IL-6[SMD=1.86,95%CI(1.46,2.27),P<0.001],IL-8 [SMD=2.16,95%CI(1.45,2.88),P<0.001],TNF-α[SMD=2.16,95%CI(1.56,2.76),P<0.001],C-reactive protein [SMD=1.63, 95%CI(0.56,2.70),P<0.001] and endotoxin [SMD=2.39,95%CI(1.33,3.45),P<0.001], and it also can significantly improve IL-10[SMD=-2.75,95%CI(-3.84,-1.67),P<0.001], with statistical significance. CONCLUSIONS: Based on conventional trecotment,Xuebijing injection can significantly improve inflammatory mediators in patients with SAP.
期刊: 2016年第27卷第33期
作者: 张映,柯正华
AUTHORS: ZHANG Ying,KE Zhenghua
关键字: 血必净注射液;重症急性胰腺炎;白细胞介素;肿瘤坏死因子;C反应蛋白;内毒素;Meta分析
KEYWORDS: Xuebijing injection; Severe acute pancreatitis; Interleukin; Tumor necrosis factor; C-reactive protein; Endotoxin; Meta-analysis
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