生长抑素与泮托拉唑联合凝血酶治疗急性上消化道出血的疗效分析
x

请在关注微信后,向客服人员索取文件

篇名: 生长抑素与泮托拉唑联合凝血酶治疗急性上消化道出血的疗效分析
TITLE:
摘要: 目的:探讨生长抑素与泮托拉唑联合凝血酶治疗急性上消化道出血(AUGH)的疗效和安全性。方法: 回顾性分析136例AUGH患者资料,按治疗方案的不同分为对照组(68例)和观察组(68例)。对照组患者给予注射用泮托拉唑8 mg/h,持续静脉泵入72 h+注射用凝血酶2 000 U,加入0.9%氯化钠注射液15 ml中口服,bid。观察组患者在对照组治疗的基础上加用注射用生长抑素0.25 mg/h,持续静脉泵入72 h(首次使用注射用生长抑素时应先静脉注射生长抑素0.25 mg约3~5 min)。两组疗程均为1周。观察两组患者的临床疗效、止血时间、住院时间、24 h止血率、48 h止血率、再出血率及不良反应发生情况。结果:观察组患者总有效率、24 h止血率、48 h止血率均显著高于对照组,止血时间、住院时间均显著短于对照组,再出血率显著低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:生长抑素与泮托拉唑联合凝血酶治疗AUGH的疗效较好,可缩短止血时间和住院时间,降低再出血率,且不增加不良反应的发生。
ABSTRACT: OBJECTIVE: To investigate the efficacy and safety of somatostatin, pantoprazole combined with thrombin in the treatment of acute upper gastrointestional hemorrhage (AUGH). METHODS: Clinical data of 136 AUGH was retrospectively analyzed and divided into control group(68 cases) and observation group(68 cases). Control group received pantoprazole 8 mg/h continuous micro-infusion for 72 h+thrombin 2 000 U adding into 15 ml 0.9% Sodium chloride injection, 2 times/d. Observation group was additionally given somatostatin 0.25 mg/h continuous micro-infusion maintaining 72 h. 0.25 mg somatostatin was intravenously injected for 3-5 min when the first use of somatostatin. They were treated for 1 week. The clinical efficacy, hemostatic time, hospitalization time, 24 h hemostatic rate, 48 h hemostatic rate and rehemorrage rate in 2 groups were observed, and the incidence of adverse reactions was recorded. RESULTS:Total effective rate, 24 h hemostatic rate, 48 h hemostatic rate in observation group were significantly higher than control group, hemostatic time, hospitalization time were significantly shorter than control group, with statistical significances (P<0.05). And there was no significant difference in the incidence of total adverse reactions (P>0.05). CONCLUSIONS: Somatostatin, pantoprazole combined with thrombin show good efficacy in the treatment of AUGH, it can shorten hemostatic time and hospitalization time, reduce rehemorrage rate, and do not increase the incidence of adverse reactions.
期刊: 2016年第27卷第33期
作者: 聂军,吴伟民
AUTHORS: NIE Jun,WU Weiming
关键字: 生长抑素;泮托拉唑;凝血酶;急性上消化道出血;疗效;安全性
KEYWORDS: Somatostatin; Pantoprazole; Thrombin; AUGH; Efficacy; Safety
阅读数: 248 次
本月下载数: 2 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!