丹参川芎嗪注射液联合曲美他嗪治疗病毒性心肌炎急性期的临床观察
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篇名: 丹参川芎嗪注射液联合曲美他嗪治疗病毒性心肌炎急性期的临床观察
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摘要: 目的:观察丹参川芎嗪注射液联合曲美他嗪治疗病毒性心肌炎急性期的临床疗效及安全性。方法:将110例病毒性心肌炎急性期患者按随机数字表法分为对照组和观察组,各55例。两组患者均给予果糖二磷酸钠、高蛋白质饮食等基础治疗。对照组患者给予盐酸曲美他嗪片20 mg,po,tid;观察组患者在对照组基础上给予丹参川芎嗪注射液5 ml加入5%葡萄糖注射液250 ml中,ivgtt,qd。两组患者均连续治疗30 d。比较两组患者临床疗效及心电图S-T段疗效,并观察两组患者治疗前后血清炎性因子[白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)]、氧化应激因子[丙二醛(MDA)、超氧化物歧化酶(SOD)]、心肌酶谱[肌酸激酶(CK)及乳酸脱氢酶(LDH)]及不良反应发生情况。结果:观察组患者临床总有效率与心电图S-T段总有效率分别为94.5%、90.9%,显著高于对照组的85.4%和81.8%,差异有统计学意义(P<0.05)。两组患者治疗前IL-6、hs-CRP、MDA、CK、LDH、SOD水平比较,差异无统计学意义(P<0.05);治疗后,两组患者IL-6、hs-CRP、SOD、CK及LDH显著降低,MDA显著升高,且观察组明显优于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丹参川芎嗪注射液联合曲美他嗪治疗病毒性心肌炎急性期疗效显著,能有效改善患者心电图情况及实验室检查指标,且安全性较好。
ABSTRACT: OBJECTIVE: To observe clinical efficacy and safety of Salvia tetramethylpyrazine injection combined with  trimetazidinein the treatment of acute phase of viral myocarditis. METHODS: 110 patients with acute phase of viral myocarditis were divided into control group and observation group according to random number table, with 55 cases in each group. Both groups received basic treatment as fructose sodium dipllosphate, high-protein diet. Control group was given Trimetazidine hydrochloride tablet 20 mg, po, tid; observation group was additionally given Salvia tetramethylpyrazine injection 5 ml added into 5% Glucose injection 250 ml, ivgtt, qd. Both groups received treatment for consecutive 30 d. The clinical efficacy and therapeutic efficacy of electrocardiogram S-T segment were compared between 2 groups. The levels of serum inflammatory factors (IL-6, hs-CRP), oxidative stress factors (MDA, SOD),  cardiac enzymes (CK, LDH) and the occurrence of ADR were compared between 2 groups before and after treatment. RESULTS: The total effective rate and total effective rate of electrocardiogram S-T segment in observation group were 94.5% and 90.9%, which was significantly higher than those of control group (85.4% and. 81.8%), with statistical significance (P<0.05). There was no statistical significance in the levels of IL-6, hs-CRP, MDA, SOD, CK and LDH between 2 groups before treatment (P>0.05). After treatment, the levels of IL-6, hs-CRP, MDA, SOD, CK and LDH were decreased significantly in 2 groups, while MDA was significantly increased; the observation group was significantly better than the control group, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS: Salvia tetramethylpyrazine injection combined with trimetazidine is effective in the treatment of acute phase of viral myocarditis, can effectively improve electrocardiogram and lab indexes with good safety.
期刊: 2016年第27卷第32期
作者: 李倩,高晓峰
AUTHORS: LI Qian,GAO Xiaofeng
关键字: 丹参川芎嗪注射液;曲美他嗪;病毒性心肌炎;心电图;临床疗效
KEYWORDS: Salvia tetramethylpyrazine injection; Trimetazidine; Viral myocarditis; Electrocardiogram; Clinical efficacy
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