化风丹血清药物化学的初步研究
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篇名: 化风丹血清药物化学的初步研究
TITLE:
摘要: 目的:对化风丹血清药物化学进行研究,初步探讨其药效物质基础。方法:采用超高效液相色谱-飞行时间质谱联用法,同时建立化风丹提取物以及大鼠ig化风丹(6 g/kg)、药母(1.37 g/kg)、药母阴性样品(5.73 g/kg)提取物后含药血清的指纹图谱,分别在正、负离子检测模式下通过比较化风丹和含药血清的指纹图谱,初步鉴定化风丹在大鼠血中移行成分及其代谢产物。结果:在负离子模式下含药血清中共发现8个药源性成分(其中3个为原型成分,5个可能为代谢产物),有6个来自药母;在正离子模式下含药血清中共发现9个药源性成分(其中2个为原型成分,7个可能为代谢产物),有6个来自药母。结论:初步确定了化风丹的入血成分,其入血成分主要来自药母。
ABSTRACT: OBJECTIVE: To study the serum pharmacochemistry of Huafengdan, and to investigate its active component base preliminarily. METHODS: UPLC-Q-TOF/MS was used to establish the fingerprints of Huafengdan and drug-containing serum of rats after intragastric administration of extract of Huafengdan (6 g/kg), Yaomu (1.37 g/kg) and Yaomu negative sample (5.73 g/kg). The fingerprints of Huafengdan and drug-containing serum were compared under positive and negative ion model, in order to preliminarily indentify the components absorbed into blood and metabolites of Huafengdan. RESULTS: Under negative ion model, 8 drug-induced constituents (3 prototype components, 5 possible metabolites) were found in drug-containing serum, 6 of which were from Yaomu. Under positive ion model, 9 drug-induced constituents (2 prototype components, 7 possible metabolites) were found in drug-containing serum, 6 of which were from Yaomu. CONCLUSIONS: The components absorbed into blood of Huafengdan are confirmed preliminarily and mainly come from Yaomu.
期刊: 2016年第27卷第28期
作者: 向文英,杨武,梅朝叶,王永林,李勇军,黄勇
AUTHORS: XIANG Wenying,YANG Wu,MEI Chaoye,WANG Yonglin,LI Yongjun,HUANG Yong
关键字: 血清药物化学;化风丹;药母;指纹图谱;含药血清;移行成分;大鼠
KEYWORDS: Serum pharmacochemistry; Huafengdan; Yaomu; Fingerprint; Drug-containing serum; Absorbed component; Rats
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