依巴斯汀联合除湿止痒软膏治疗手部角化皲裂性湿疹的临床观察
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篇名: 依巴斯汀联合除湿止痒软膏治疗手部角化皲裂性湿疹的临床观察
TITLE:
摘要: 目的: 观察依巴斯汀片联合除湿止痒软膏治疗手部角化皲裂性湿疹的临床疗效及安全性。方法:将135例手部角化皲裂性湿疹患者按治疗方案分为对照A组(45例)、对照B组(43例)及治疗组(47例)。对照A组患者口服依巴斯汀片,每次10 mg,qd;对照B组患者单用除湿止痒软膏,早晚1次,以薄层涂于患处;治疗组患者口服同等剂量依巴斯汀片联合除湿止痒软膏涂于患处。3组患者均连续治疗4周。观察3组患者临床疗效及治疗前后瘙痒、皮损面积、角化、皲裂和视觉模拟(VAS)评分,并比较不良反应发生情况。结果:治疗组患者临床总有效率为68.09%,明显高于对照A组的42.22%及对照B组的16.28%,差异有统计学意义(P<0.05)。3组患者治疗前瘙痒、皮损面积、角化、皲裂及VAS评分比较,差异无统计学意义(P>0.05);治疗后,3组患者上述评分均显著降低,且治疗组显著低于对照A组及对照B组,差异均有统计学意义(P<0.05)。3组患者不良反应均轻微,且发生率比较,差异无统计学意义(P>0.05)。结论:依巴斯汀片联合除湿止痒软膏治疗手部角化皲裂性湿疹疗效显著,能明显改善患者皮肤症状,且安全性较高。
ABSTRACT: OBJECTIVE: To observe clinical efficacy and safety of Ebastine tablet combined with Chushi zhiyang ointment in the treatment of hand keratinizing chapped eczema. METHODS: 135 cases of hand keratinizing chapped eczema were divided into control group A (45 cases), control group B (43 cases) and treatment group (47 cases) according to treatment regimen. Control group A was orally given Ebastine tablet, 10 mg each time, qd; control group B was given Chushi zhiyang ointment alone, twice a day, morning and evening, applying thin layer of ointment on the affected area; treatment group was given same dose of Ebastine tablet orally and applied Chushi zhiyang ointment on the affected area. 3 groups received treatment for consecutive 4 weeks. Clinical efficacies of 3 groups were observed as well as the scores of pruritus, skin lesion area, keratinization, rhagades and VAS before and after treatment. The occurrence of ADR was compared among 3 groups. RESULTS: The total effective rate of treatment group was 68.09%, which was significantly higher than that of group A (42.22%) and control group B (16.28%), with statistical significance (P<0.05). There was no statistical significance in the scores of pruritus, skin lesion area, keratinization, rhagades and VAS among 3 groups before treatment (P>0.05). After treatment, above scores of 3 groups decreased significantly, and those of treatment group were significantly lower than those of control group A and B, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR among 3 groups (P>0.05). CONCLUSIONS: Ebastine tablet combined with Chushi zhiyang ointment is effective for hand keratinizing chapped eczema, and can significantly improve the skin of patients with good safety.
期刊: 2016年第27卷第26期
作者: 郑颖,任建军,霍伟红,梁娟,周哲
AUTHORS: ZHENG Ying,REN Jianjun,HUO Weihong,LIANG Juan,ZHOU Zhe
关键字: 依巴斯汀片;除湿止痒软膏;角化皲裂性湿疹;临床疗效
KEYWORDS: Ebastine tablet; Chushi zhiyang ointment; Keratinizing chapped eczema; Clinical efficacy
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