3种药物性肝损伤诊断评分系统的应用及比较
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篇名: 3种药物性肝损伤诊断评分系统的应用及比较
TITLE:
摘要: 目的:分析比较药物性肝损伤(DILI)因果关系评价表(RUCAM)、Maria标准及DDW-J标准3种评分系统诊断DILI的一致性,并进行应用评价。方法:回顾性分析了RUCAM评分≥3分的122例药物性肝损伤患者的临床资料,分别应用Maria标准和DDW-J标准评分系统进行量化评分,采用χ2检验进行统计学分析。结果:122例患者中,DDW-J标准评分提示“可能性”大和“有可能”者120例(98.4%),显著高于Maria标准评分提示为“有可能”者的58例(47.5%),差异有统计学意义(P<0.05),提示DDW-J标准较Maria标准更接近RUCAM评分结果。结论:DDW-J标准评分系统优于Maria标准评分系统,且与RUCAM评分系统在诊断药物性肝损伤中的效果相近;RUCAM评分系统仍是目前较为准确、可操作性高的DILI诊断评价系统。
ABSTRACT: OBJECTIVE: To analyze and compare the congruity between Maria and DDW-J standard and Roussel uclaf causality assessment method(RUCAM) for diagnosing drug-induced liver injury (DILI), and evaluate its application. METHODS: In retrospective analysis, the clinical data of 122 patients with DILI with RUCAM ≥3 scores was quantitatively scored by Maria and DDW-J standard, χ2 test was conducted for statistical analysis. RESULTS: Among the 122 cases, 120 cases (98.4%) were classified as “likely and possible” by DDW-J standard, which was significantly higher than the 58 cases (47.5%) that classified as “possible” by Maria standard, with statistical significance; and compared with Maria standard, DDW-J standard was more closer to RUCAM scoring results. CONCLUSIONS: DDW-J standard is superior to Maria standard, and close to RUCAM scoring results for DILI; RUCAM is still the DILI diagnostic evaluation system with high accuracy and operability.
期刊: 2016年第27卷第26期
作者: 徐琴,刘浩,张跃新
AUTHORS: XU Qin,LIU Hao,ZHANG Yuexin
关键字: 药物性肝损伤;诊断标准;RUCAM;Maria标准;DDW-J标准
KEYWORDS: Drug-induced liver injury; Diagnostic criterion; RUCAM; Maria standard; DDW-J standard
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