丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的临床观察
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篇名: 丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的临床观察
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摘要: 目的:观察丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的疗效和安全性。方法:78例老年抑郁症伴焦虑症状患者随机分为对照组(39例)和观察组(39例)。对照组患者给予盐酸帕罗西汀片20~40 mg,每日早餐后半小时内顿服;观察组患者在对照组治疗的基础上给予盐酸丁螺环酮片5~10 mg,口服,每日3次。两组疗程均为8周。观察两组患者的临床疗效,治疗前及治疗2、4、8周后的汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分及治疗过程中的副反应量表(TESS)评分。结果: 观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。对照组患者治疗4、8周后HAMD评分及治疗8周后 HAMA评分,观察组患者治疗2、4、8周后HAMD评分及HAMA评分均显著低于同组治疗前,随治疗时间延长逐渐降低,且观察组低于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗过程中,两组患者TESS评分比较,差异均无统计学意义(P>0.05)。结论:丁螺环酮联合帕罗西汀治疗老年抑郁症伴焦虑症状的疗效优于单用帕罗西汀,且安全性较好。
ABSTRACT: OBJECTIVE: To observe the efficacy and safety of paroxetine combined with buspirone in the treatment of geriatric depression with anxiety. METHODS: 78 patients with geriatric depression with anxiety were randomly divided into control group (39 cases) and observation group (39 cases). Control group received 20-40 mg Paroxetine hydrochloride tablet, within half an hour after breakfast. Observation group additionally received 5-10 mg Buspirone hydrochloride tablet for 3 times. The treatment course for both groups was 8 weeks. Clinical efficacy, HAMD, HAMA and TESS before and after 2, 4 and 8 weeks of treatment in 2 groups were observed. RESULTS: The total effective rate in observation group was significantly higher than control group, the difference was statistically significant (P<0.05). HAMD after 4 and 8 weeks, HAMA after 8 weeks in control group, HAMD and HAMA after 2, 4 and 8 weeks in observation group were significantly lower than before, and it gradually decreased by time prolonged, observation group was lower than control group, the differences were statistically significant (P<0.05 or P<0.01). And there was no significant difference in the TESS rating in 2 groups before and after treatment (P>0.05). CONCLUSIONS: The efficacy of buspirone combined with paroxetine is superior to paroxetine alone in the treatment of geriatric depression with anxiety, with better safety.
期刊: 2016年第27卷第21期
作者: 蒋硕,曾骥,周勇
AUTHORS: JIANG Shuo,ZENG Ji,ZHOU Yong
关键字: 丁螺环酮;帕罗西汀;老年抑郁症;焦虑;疗效;安全性
KEYWORDS: Buspirone; Paroxetine; Geriatric depression; Anxiety; Efficacy; Safety
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