甲氨蝶呤、米非司酮联合化瘀消癥汤治疗子宫瘢痕妊娠的临床观察
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篇名: 甲氨蝶呤、米非司酮联合化瘀消癥汤治疗子宫瘢痕妊娠的临床观察
TITLE:
摘要: 目的:观察甲氨蝶呤(MTX)、米非司酮联合化瘀消癥汤治疗子宫瘢痕妊娠的疗效和安全性。方法: 86例子宫瘢痕妊娠患者随机分为对照组(43例)和观察组(43例)。对照组患者于超声引导下局部注射MTX 50 mg,每日1次+米非司酮片50 mg,口服,每日2次;观察组患者在对照组治疗的基础上给予化瘀消癥汤100 ml,温服,每日2次。两组疗程均为15 d。观察两组患者的临床疗效,治疗前及治疗后第7、14、28天血人绒毛膜促性腺激素(HCG)水平,包块直径及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后第7、14、28天两组患者血HCG水平和包块直径均显著低于同组治疗前,随治疗时间延长逐渐降低,且研究组低于对照组,差异均有统计学意义(P<0.05或P<0.01)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:MTX、米非司酮联合化瘀消癥汤治疗子宫瘢痕妊娠的疗效和安全性均较好。
ABSTRACT: OBJECTIVE: To investigate the efficacy and safety of methotrexate (MTX),Mifepristone combined with Huayu xiaozheng decoction in the treatment of uterine scar pregnancy. METHODS: 86 patients with uterine scar pregnancy were randomly divided into control group (43 cases) and observation group (43 cases). Control group orally received 50 mg ultrasound-guided local injections of MTX,once a day+50 mg Mifepristone tablet, twice a day; observation group additionally received 100 ml Huayu xiaozheng decoction, twice a day with warm temperature. The treatment course for both groups was 15 d. Clinical efficacy, HCG levels, mass diameter before and after 7, 14 and 28 d of treatment, and the incidence of adverse reactions in 2 groups were observed. RESULTS: The total effective rate in observation group was significantly higher than control group, the difference was statistically significant (P<0.05). HCG levels and mass diameter after 7, 14 and 28 d were significantly lower than before, it gradually reduced by time prolonged, and research group was lower than control group, the differences were statistically significant (P<0.05 or P<0.01). And there was no significant difference in the incidence of adverse reactions (P>0.05). CONCLUSIONS: Ultrasound-guided local injections of MTX combined with Huayu xiaozheng decoction shows good efficacy and safety in the treatment of uterine scar pregnancy
期刊: 2016年第27卷第21期
作者: 彭月享,黄敏,曹辉,张媛媛,王静,杨晓新
AUTHORS: PENG Yuexiang,HUANG Min,CAO Hui,ZHANG Yuanyuan,WANG Jing,YANG Xiaoxin
关键字: 甲氨蝶呤;米非司酮;化瘀消癥汤;子宫瘢痕妊娠;疗效;安全性
KEYWORDS: Methotrexate; Mifepristone; Huayu xiaozheng decoction; Uterine scar pregnancy; Efficacy; Safety
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