坦索罗辛、硝苯地平、消旋山莨菪碱治疗输尿管下段结石的疗效和安全性比较
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篇名: 坦索罗辛、硝苯地平、消旋山莨菪碱治疗输尿管下段结石的疗效和安全性比较
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摘要: 目的:比较坦索罗辛、硝苯地平、消旋山莨菪碱治疗输尿管下段结石的疗效和安全性。方法:160例输尿管下段结石患者随机分为A组(40例)、B组(40例)、C组(40例)和D组(40例)。所有患者均需大量饮水,每日尿量达到>2 000 ml。在此基础上,A组患者给予盐酸坦索罗辛缓释胶囊0.4 mg,口服, 每日1次;B组患者给予硝苯地平片10 mg,口服,每日3次;C组患者给予消旋山莨菪碱片10 mg,口服,每日3次;D组患者除适度增加饮水外不应用任何辅助排石药。各组疗程均为2周。观察各组患者的临床疗效,排石时间、排石大小、残留结石大小及不良反应发生情况。结果:总有效率A组>C组>B组>D组,差异均有统计学意义(P<0.05);排石时间A组<B、C组<D组,差异均有统计学意义(P<0.05),B、C组比较差异无统计学意义(P>0.05);排石大小A组>C组>B、D组,差异均有统计学意义(P<0.05),B、D组比较差异无统计学意义(P>0.05);残留结石大小A组<B组<C组<D组,差异均有统计学意义(P<0.05)。各组患者治疗期间均未见明显不良反应发生。结论:坦索罗辛治疗输尿管下段结石的疗效显著优于硝苯地平和消旋山莨菪碱,硝苯地平与消旋山莨菪碱疗效相当,三者安全性均较好。
ABSTRACT: OBJECTIVE: To compare the efficacy and safety of tamsulosin or nifedipine or racanisodamine in the treatment of lower ureteral calculi. METHODS:160 patients with lower ureteral calculi were randomly divided into group A (40 cases), group B (40 cases), group C (40 cases) and group D (40 cases). All patients drank plenty of water to make daily urine output more than 2 000 ml. Based on it, group A orally received 0.4 mg Tamsulosin hydrochloride sustained release capsule, once a day. Group B orally received 10 mg Nifedipine tablet, 3 times a day. Group C orally received 10 mg racanisodamine tablet, 3 times a day. Group D received no other drugs except for increasing drinking. The treatment course for all groups was 2 weeks. Clinical efficacy, lithagogue time, lithagogue size, residual calculi size and the incidence of adverse reactions in all groups were observed. RESULTS: The total effective rate in group A was higher than group C, which was higher than group B and group D, the differences were statistically significant (P<0.05). Lithagogue time in group A was shorter than group B and group C, which was shorter than group D, the differences were statistically significant (P<0.05), while there was no significant difference between group B and group C(P>0.05). Lithagogue size in group A was more than group C, which was more than group B and group D, the differences were statistically significant (P<0.05), while there was no significant difference between group B and group D (P>0.05). Residual calculi size in group A was less than group B, which was less than group C and group D, the differences were statistically significant (P<0.05). And there were no severe adverse reactions in all groups. CONCLUSIONS: The efficacy of tamsulosin is superior to nifedipine and racanisodamine in the treatment of lower ureteral calculi, while nifedipine and racanisodamine show similar efficacy, with better safety.
期刊: 2016年第27卷第21期
作者: 童维,王晋忠
AUTHORS: TONG Wei,WANG Jinzhong
关键字: 输尿管下段结石;坦索罗辛;硝苯地平;消旋山莨菪碱;疗效;安全性
KEYWORDS: Lower ureter calculi; Tamsulosin; Nifedipine; Racanisodamine; Efficacy; Safety
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