多指标综合评分法结合正交试验优化心力康颗粒中红参与丹参的混合醇提工艺
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篇名: 多指标综合评分法结合正交试验优化心力康颗粒中红参与丹参的混合醇提工艺
TITLE:
摘要: 目的:优化心力康颗粒中红参与丹参的混合醇提工艺。方法:以红参中3种人参皂苷Rg1、Re、Rb1和丹参中丹参酮ⅡA、丹酚酸B 等5种成分的含量的加权系数综合评分为考察指标,以乙醇体积分数、加醇倍数和提取次数为考察因素,设计L9(34)正交试验优化混合醇提工艺并进行验证试验。结果:红参和丹参最优混合醇提工艺为以6倍量70%的乙醇回流提取3次,每次2 h;验证试验中人参皂苷Rg1、Re、Rb1、丹参酮ⅡA和丹酚酸B的平均含量分别为3.963 8、0.757 3、4.986 2、0.964 7、27.662 5 mg/g,综合评分为0.96(RSD=1.26%,n=3)。结论:采用多指标综合评分法结合正交试验优化的心力康颗粒中红参与丹参的醇提工艺稳定、合理、可行。
ABSTRACT: OBJECTIVE: To optimize the ethanol mixed-extraction technology of Red ginseng and Salvia miltiorrhiza in Xinlikang granules. METHODS: L9(34) orthogonal test was adopted to optimize ethanol mixed-extraction technology with ethanol volume fraction, amount of ethanol and extraction times as factors using weighting coefficient comprehensive score of the contents of ginsenoside Rg1, Re and Rb1 in R. ginseng and the contents of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza as index; and the verification test was detected. RESULTS: Optimal mixed-ethanol extraction technology was as follows as 6-fold 70% ethanol, reflux extracting for 3 times, 2 h each time. In verification test, average contents of ginsenosides Rg1, Re, Rb1 in R. ginseng and those of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza were 3.963 8, 0.757 3, 4.986 2, 0.964 7, 27.662 5 mg/g, respectively, and comprehensive score was 0.96 (RSD=1.26%, n=3). CONCLUSIONS: Ethanol extraction technology of R. ginseng and S. miltiorrhiza in Xinlikang granules optimized by multiple indexes comprehensive score combined with orthogonal test is stable, reasonable and feasible.
期刊: 2016年第27卷第19期
作者: 王少辰,郭宇洁,任烨,吴红金,刘建勋
AUTHORS: WANG Shaochen,GUO Yujie,REN Ye,WU Hongjin,LIU Jianxun
关键字: 心力康颗粒;红参;丹参;人参皂苷;丹参酮ⅡA;丹酚酸B;多指标综合评分;正交试验
KEYWORDS: Xinlikang granules; Red ginseng; Salvia miltiorrhiza; Ginsenoside; Tanshinone ⅡA; Salvianolic acid B; Multiple indexes comprehensive evaluation; Orthogonal test
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