阿日很浩日-11味对小鼠急性酒精中毒的预防作用研究
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篇名: 阿日很浩日-11味对小鼠急性酒精中毒的预防作用研究
TITLE:
摘要: 目的:研究阿日很浩日-11味对小鼠急性酒精中毒的预防作用。方法:将48只小鼠随机分为模型组(羧甲基纤维素钠)和阿日很浩日-11味低、中、高剂量组[1.23 、2.46、4.92 g(生药)/kg],每组12只;各组小鼠均于ig相应药物30 min后ig 56%白酒,复制急性酒精中毒模型,测定小鼠翻正反射消失时间和翻正反射恢复时间。将160只小鼠同法分组、给药和造模,每组40只,分别于酒后0.5、1、2、3 h各选10只小鼠测定其血液中乙醇浓度和肝乙醇脱氢酶(ADH)活性;另选10只小鼠作为正常对照(ig羧甲基纤维素钠)。结果:与模型组比较,阿日很浩日-11味各剂量组小鼠翻正反射消失时间延长、翻正反射恢复时间缩短,酒后0.5、1、2 h 血液中乙醇浓度降低、肝ADH活性升高(P<0.05或P<0.01),其中酒后1 h最明显;酒后3 h,阿日很浩日-11味高剂量组小鼠血液中乙醇浓度降低、肝ADH活性升高(P<0.05),其余剂量组差异无统计学意义(P>0.05)。结论:阿日很浩日-11味对小鼠急性酒精中毒有一定的预防作用,并对酒后血液中乙醇浓度和肝ADH活性有一定的正向调节作用。
ABSTRACT: OBJECTIVE: To study the preventive effects of arhinhor-11 on acute alcoholism in mice. METHODS: 48 mice were randomly divided into model group (sodium carboxymethyl cellulose), arhinhor-11 low-dose, medium-dose and high-dose groups [1.23, 2.46, 4.92 g(crude drug)/kg], with 12 mice in each group. Each group was given relevant medicine intragastrically, and 30 min later given 56% liquor intragastrically to induce acute alcoholism model. The disappearance time and recovery time of righting reflex were determined. 160 mice were grouped, given medicine and modeled with the same method, with 40 mice in each group. The alcohol concentration and alcohol dehydrogenase (ADH) activity in liver of 10 mice were determined 0.5, 1, 2, 3 h after giving alcohol. Other 10 mice were included in normal control (ig administration of sodium carboxymethyl cellulose). RESULTS: Compared with model group, the disappearance time of righting reflex were prolonged while recovery time shortened in arhinhor-11 groups, and alcohol concentration and ADH activity increased 0.5, 1, 2, 3 h after giving alcohol (P<0.05 or P<0.01), especially 1 h after giving alcohol. 3 h after giving alcohol, alcohol concentration in blood of arhinhor-11 high-dose group decreased while ADH activity increased (P<0.05); there was no statistical significance among other arhinhor-11 groups (P>0.05). CONCLUSIONS: Arhinhor-11 has preventive effect on acute alcoholism in mice. It has a positive control effects on the alcohol concentration in blood and ADH activity in liver.
期刊: 2016年第27卷第19期
作者: 包勒朝鲁,布仁,红梅,阿拉坦敖日格勒,金花,那生桑
AUTHORS: Baolechaolu,Buren,HONG Mei,Alatan’aorigele,JIN Hua,Nashengsang
关键字: 阿日很浩日-11味;急性酒精中毒;翻正反射;乙醇浓度;乙醇脱氢酶;小鼠
KEYWORDS: Arhinhor-11; Acute alcoholism; Righting reflex; Alcohol concentration; Alcohol dehyrogenase; Mice
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