丹参酮胶囊对多囊卵巢综合征大鼠糖脂代谢及性激素的影响
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篇名: 丹参酮胶囊对多囊卵巢综合征大鼠糖脂代谢及性激素的影响
TITLE:
摘要: 目的:研究丹参酮胶囊对多囊卵巢综合征(PCOS)大鼠糖脂代谢及血清性激素水平的影响。方法:选取90只雌性SD大鼠,随机分为正常组(蒸馏水)、模型组(蒸馏水)、阳性对照组(二甲双胍200 mg/kg)和丹参酮胶囊低、中、高剂量组(30、60、90 mg/kg),每组15只。除正常组外其余各组大鼠复制PCOS模型,建模后各组大鼠ig相应药物,每天1次,连续给药28 d。比较干预前、干预28 d后各组大鼠的排卵率,检测干预后各组大鼠体质量、脂肪湿质量、空腹胰岛素(FINS)、空腹血糖(FPG)、葡萄糖曲线下面积(AUC)、胰岛素敏感指数(HOMA-IR、ISI)和血清中促卵泡生成素(FSH)、促黄体生成素(LH)、睾酮(T)变化。结果:与正常组比较,模型组大鼠停止排卵,体质量、脂肪湿质量、FINS、FPG、葡萄糖AUC、HOMA-IR、FSH、LH、T均明显升高,ISI明显降低(P<0.05)。与模型组比较,阳性对照组和丹参酮胶囊各剂量组大鼠干预后排卵率明显升高,体质量(丹参酮胶囊低剂量组除外)、脂肪湿质量(丹参酮胶囊低剂量组除外)、FINS、FPG、葡萄糖AUC、HOMA-IR、FSH、LH、T均明显降低,ISI明显升高(P<0.05),其中丹参酮胶囊高剂量组和阳性对照组效果最明显。结论:丹参酮胶囊能调节PCOS大鼠的糖脂代谢和血清性激素分泌紊乱。
ABSTRACT: OBJECTIVE: To study the effects of Tanshinone capsules on glucose and lipid metabolism and serum sex hormone level in rats with polycystic ovary syndrome (PCOS). METHODS: 90 female SD rats were randomly divided into normal group (distilled water), model group (distilled water), positive control group (metformin 200 mg/kg) and Tanshinone capsules low- dose, medium-dose and high-dose groups (30, 60, 90 mg/kg), with 15 rats in each group. Those groups were induced PCOS model except for normal group; after modeling, those groups were given relevant medicine intragastrically for consecutive 28 d, once a day. The ovulation rate was compared before intervention and 28 d after intervention. Body weight, fat wet weight, fasting insulin (FINS), fasting blood-glucose (FPG), AUC of glucose, HOMA-IR, ISI, serum levels of FSH, LH and T were detected. RESULTS: Compared with normal group, anovulation, body weight, fat wet weight, FINS, FPG, AUC of glucose, HOMA-IR, FSH, LH and T were all increased significantly in model group, while ISI decreased significantly (P<0.05). Compared with model group, ovulation rate and ISI of positive control group and Tanshinone capsules groups were increased significantly after intervention, while body weight (except for Tanshinone capsules low-dose group), fat wet weight (except for Tanshinone capsules low-dose group), FINS, FPG, AUC of glucose, HOMA-IR, FSH, LH and T were all decreased significantly (P<0.05), especially in Tanshinone capsules high-dose group and positive control group. CONCLUSIONS: Tanshinone capsules can regulate glucose and lipid metabolism and serum sex hormone secretion disorder in PCOS rats.
期刊: 2016年第27卷第19期
作者: 虎亚光,岳嘉,李金娟,刘建鸿,陈丽,张书楠
AUTHORS: HU Yaguang,YUE Jia,LI Jinjuan,LIU Jianhong,CHEN Li,ZHANG Shunan
关键字: 丹参酮胶囊;多囊卵巢综合征;大鼠;糖脂代谢;性激素
KEYWORDS: Tanshinone capsules; Polycystic ovarian syndrome; Rats; Glucose and lipid metabolism; Sex hormone
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