妇炎消泡腾片治疗湿热下注型霉菌性阴道炎的临床观察
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篇名: 妇炎消泡腾片治疗湿热下注型霉菌性阴道炎的临床观察
TITLE:
摘要: 目的:观察妇炎消泡腾片治疗湿热下注型霉菌性阴道炎的疗效和安全性。方法: 80例湿热下注型霉菌性阴道炎患者随机均分为对照组和观察组。对照组患者给予制霉素阴道栓1粒,于月经干净后第3天开始用药,每晚1次;观察组患者给予妇炎消泡腾片1片,于月经干净后第3天开始用药,每晚1次。每晚用药前先用2%~4%碳酸氢钠溶液清洗外阴,取平卧位将药送至阴道深部。两组均以 7 d为1个疗程,共治疗3个疗程。治疗期间禁止性生活,不同时使用其他抗菌药物。观察两组患者的临床疗效,治疗前后各中医症状评分、阴道乳酸杆菌阳性例数及转阳率,复发率及不良反应发生情况。结果:两组患者总有效率、复发率、不良反应发生率比较,差异均无统计学意义(P>0.05)。治疗前,两组患者各中医症状评分、阴道乳酸杆菌阳性例数及转阳率比较,差异均无统计学意义(P>0.05)。治疗后,两组患者各中医症状评分均显著低于同组治疗前,且观察组阴部瘙痒、白带色质、小腹作痛评分均显著低于对照组;观察组患者阴道乳酸杆菌阴性例数、转阳率均显著高于同组治疗前及对照组,差异均有统计学意义(P<0.05);对照组患者治疗前后阴道乳酸杆菌阳性例数、转阳率比较,差异均无统计学意义(P>0.05)。结论:妇炎消泡腾片治疗湿热下注型霉菌性阴道炎疗效显著,复发率较低,可显著改善临床症状,安全性较好。
ABSTRACT: OBJECTIVE:To observe the efficacy and safety of Fuyanxiao effervescent tablet in the treatment of damp-heat pouring downward syndrome of fungal vaginitis. METHODS: 80 patients with damp-heat pouring downward syndrome of fungal vaginitis were randomly divided into control group and observation group. Control group was given one Nystatin vaginal suppository, and the drug was given in the third day after the menstrual period ending, once every night; observation group was given one Fuyanxiao effervescent tablet, and the drug was given in the third day after the menstrual period ending, once every night. 2%-4% Sodium bicarbonate solution was used for vulva cleaning before taking the medicine at night, then patients kept lying flat to let the medicine going into the vaginal depths. There were totally 3 treatment courses with 7 days each. During the treatment, sexual activities and antibiotics were prohibited. The clinical efficacy, TCM symptom scores, vaginal lactobacillus positive rate and recurrence rate before and after treatment, and incidence of adverse reactions in 2 groups were observed. RESULTS: There were no significant differences in the total effective rate, recurrence rate and incidence of adverse reactions (P>0.05). Before treatment, there were no significant differences in the TCM symptoms and vaginal lactobacillus positive rate(P>0.05); after treatment, TCM symptoms in 2 groups were significantly lower than before, genital itching, leucorrhea color-quality and lower abdomen pain in observation group were significantly lower than control group, vaginal lactobacillus positive rate in observation group were significantly higher than before and control group, the differences were statistically significant (P<0.05), and there was no significant difference in the vaginal lactobacillus positive rate(P>0.05). CONCLUSIONS: Fuyanxiao effervescent tablet shows good efficacy in the treatment of damp-heat pouring downward syndrome of fungal vaginitis and improve clinical symptoms, with no recurrence rate and good safety.
期刊: 2016年第27卷第6期
作者: 牛金茹,高艳君
AUTHORS: NIU Jinru,GAO Yanjun
关键字: 湿热下注型霉菌性阴道炎;妇炎消泡腾片;疗效;安全性
KEYWORDS: Damp-heat pouring downward syndrome of fungal vaginitis; Fuyanxiao effervescent tablet; Efficacy; Safety
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