氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的临床观察
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篇名: 氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的临床观察
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摘要: 摘 要 目的:观察氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的疗效和安全性。方法:72例单疱病毒性角膜炎患者随机均分为对照组和研究组。对照组患者给予0.15%更昔洛韦眼用凝胶1滴,每日4次;若为浅层型患者,在给予0.15%更昔洛韦眼用凝胶2~5 d后,待角膜上皮修复至荧光素染色弱阳性时+阿昔洛韦片0.2 g,口服,每日3次+吲哚美辛片25 mg,口服,每日3次;深层型患者在浅层型患者治疗的基础上给予复方托吡卡胺滴眼液1滴,早晚各1次。研究组患者若为浅层型给予0.15%更昔洛韦眼用凝胶2~5 d后,待角膜上皮修复至荧光素染色弱阳性时+0.02%氟米龙滴眼液1滴,每日4次+阿昔洛韦片(用法用量同对照组)+吲哚美辛片(用法用量同对照组);深层型患者在浅层型患者治疗的基础上给予复方托吡卡胺滴眼液(用法用量同对照组)。两组疗程均为7 d。观察两组患者的临床疗效,平均治疗时间,复发率及不良反应发生情况。结果:研究组患者总有效率显著高于对照组,平均治疗时间显著短于对照组,复发率显著低于对照组,差异均有统计学意义(P<0.05)。两组患者浅层型总有效率比较,差异无统计学意义(P>0.05);研究组患者深层型总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生,肝肾功能、血尿常规均无异常。结论:氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的疗效显著,可显著缩短病程,降低复发率,安全性较好,尤其适用于深层型单疱病毒性角膜炎患者。
ABSTRACT: OBJECTIVE: To observe the efficacy and safety of fluorometholone combined with ganciclovir in the treatment of herpes simplex keratitis. METHODS: 72 patients with herpes simplex keratitis were randomly divided into control group and study group. Control group was treated with 1 drop of 0.15% Ganciclovir ophthalmic gel, 4 times every day; shallow-type patients were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d, then 0.2 g Fluorometholone tablet was orally given when corneal epithelial repaired to positive fluorescein staining, 3 times a day + 25 mg Indomethacin tablet, orally, 3 times a day; deep-type patients were additionally treated with 1 drop of Compound tropicamide eye drop, once every morning and night. Shallow-type patients in study group were treated with 0.15% Ganciclovir ophthalmic gel for 2-5 d, then 1 drop of 0.025% Flumetholon eye drop was given when corneal epithelial repaired to positive fluorescein staining, 4 times every day+Indomethacin tablet (the same dose with control group)+Indomethacin tablet (the same dose with control group); deep-type patients were additionally treated Compound tropicamide eye drop(the same dose with control group). The treatment course for both groups was 7 d. Clinical efficacy, average treatment time, recurrence rate and incidence of adverse reactions in 2 groups were observed. RESULTS: The total effective rate in study group was significantly higher than control group, average treatment time was significantly shorter than control group, recurrence rate was significantly lower than control group, the differences were statistically significant(P<0.05). There was no significant difference in the total effective rate for shallow-type patients between 2 groups(P>0.05); the total effective rate for deep-type patients in study group was significantly higher than control group, the difference was statistically significant(P<0.05). There were no obvious adverse reactions during treatment, and liver and kidney function, blood and urine routine showed no abnormality. CONCLUSIONS: Fluorometholone combined with ganciclovir has significant efficacy in the treatment of herpes simplex keratitis, it can significantly shorten treatment course and reduce recurrence rate, with good safety, especially for deep-type patients.
期刊: 2016年第27卷第6期
作者: 刘瑄
AUTHORS: LIU Xuan
关键字: 氟米龙;更昔洛韦;单疱病毒性角膜炎;疗效;安全性
KEYWORDS: Fluorometholone; Ganciclovir; Herpes simplex keratitis; Efficacy; Safety
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